Specific Targeting of Melanotic Cells with Peptide Ligated Photosensitizers for Photodynamic Therapy

被引：13

作者：

Bigliardi, Paul Lorenz ^{[1
,2
,3
,4
]}

Rout, Bhimsen ^{[1
,2
,5
]}

Pant, Aakanksha ^{[1
]}

Krishnan-Kutty, Viknish ^{[1
]}

Eberle, Alex N. ^{[6
]}

Srinivas, Ramasamy ^{[1
]}

Burkett, Brendan Adrian ^{[5
]}

Bigliardi-Qi, Mei ^{[1
,2
]}

机构：

[1] ASTAR, Inst Med Biol, Expt Dermatol Grp, 8 Biomed Grove, Singapore, Singapore

[2] ASTAR, Clin Res Unit Skin Allergy & Regenerat, Singapore, Singapore

[3] Natl Univ Singapore Hosp, Univ Med Cluster, Singapore, Singapore

[4] NUS, Yong Loo Lin Sch Med, Singapore, Singapore

[5] ASTAR, Inst Chem & Engn Sci, Organ Chem Div, Singapore, Singapore

[6] Univ Basel, Dept Biomed, Basel, Switzerland

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

MELANOCYTE-STIMULATING HORMONE; MALIGNANT-MELANOMA; AMELANOTIC MELANOMA; CHOROIDAL MELANOMA; MSH RECEPTORS; IN-VITRO; CANCER; SKIN; PORPHYRINS; HEMATOPORPHYRIN;

D O I：

10.1038/s41598-017-15142-w

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A strategy combining covalent conjugation of photosensitizers to a peptide ligand directed to the melanocortin 1 (MC1) receptor with the application of sequential LED light dosage at near-IR wavelengths was developed to achieve specific cytotoxicity to melanocytes and melanoma (MEL) with minimal collateral damage to surrounding cells such as keratinocytes (KER). The specific killing of melanotic cells by targeted photodynamic therapy (PDT) described in this study holds promise as a potentially effective adjuvant therapeutic method to control benign skin hyperpigmentation or superficial melanotic malignancy such as Lentigo Maligna Melanoma (LMM).

引用

页数：12

共 67 条

[1] Photodynamic therapy with 5-aminolaevulinic acid-induced porphyrins of an amelanotic melanoma in vivo [J].

Abels, C ;

Fritsch, C ;

Bolsen, K ;

Szeimies, RM ;

Ruzicka, T ;

Goerz, G ;

Goetz, AE .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1997, 40 (01) :76-83

[2] New photosensitizers for photodynamic therapy [J].

Abrahamse, Heidi ;

Hamblin, Michael R. .

BIOCHEMICAL JOURNAL, 2016, 473 :347-364

[3] Epidermal growth factor receptor-targeted photosensitizer selectively inhibits EGFR signaling and induces targeted phototoxicity in ovarian cancer cells [J].

Abu-Yousif, Adnan O. ;

Moor, Anne C. E. ;

Zheng, Xiang ;

Savellano, Mark D. ;

Yu, Weiping ;

Selbo, Pal K. ;

Hasan, Tayyaba .

CANCER LETTERS, 2012, 321 (02) :120-127

[4] Laser-mediated photodynamic therapy [J].

Alexiades-Armenakas, M .

CLINICS IN DERMATOLOGY, 2006, 24 (01) :16-25

[5]

Baldea I, 2012, J PHYSIOL PHARMACOL, V63, P109

[6] Treatment of choroidal melanoma using photodynamic therapy [J].

Barbazetto, IA ;

Lee, TC ;

Rollins, IS ;

Chang, S ;

Abramson, DH .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2003, 135 (06) :898-899

[7] Killing efficacy of a new silicon phthalocyanine in human melanoma cells treated with photodynamic therapy by early activation of mitochondrion-mediated apoptosis [J].

Barge, J ;

Decréau, R ;

Julliard, M ;

Hubaud, JC ;

Sabatier, AS ;

Grob, JJ ;

Verrando, P .

EXPERIMENTAL DERMATOLOGY, 2004, 13 (01) :33-44

[8]

Bigliardi P. L., 2015, Provisional SG Patent, Patent No. [10201501747P, 10201501747]

[9] Thieme Chemistry Journal Awardees - Where are They Now? Stabilisation of Porphyrins in Tetranucleotide-Bisporphyrin Arrays by Duplex Formation with Peptide Nucleic Acid [J].

Bouamaied, Imenne ;

Stulz, Eugen .

SYNLETT, 2009, (18) :2913-2918

[10] Photodynamic therapy: update 2006 - Part 2: Clinical results [J].

Calzavara-Pinton, P. G. ;

Venturini, M. ;

Sala, R. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2007, 21 (04) :439-451

← 1 2 3 4 5 6 7 →