A facile, highly efficient and novel method for synthesis of 5-substituted 1H-tetrazoles catalysed by copper(I) chloride

被引：13

作者：

Esirden, Ibrahim ^{[1
]}

Basar, Erhan ^{[1
]}

Kaya, Muharrem ^{[2
]}

机构：

[1] Dumlupinar Univ, Fac Arts & Sci, Dept Biochem, TR-43100 Kutahya, Turkey

[2] Dumlupinar Univ, Fac Arts & Sci, Dept Chem, TR-43100 Kutahya, Turkey

来源：

CHEMICAL PAPERS | 2015年 / 69卷 / 09期

关键词：

5-substituted; 1H-tetrazoles; copper(I) chloride; sodium azide; 3+2] cycloaddition; aryl nitriles; TETRAZOLE DERIVATIVES; ANTIMICROBIAL ACTIVITY; 1,5-DISUBSTITUTED TETRAZOLES; TRIMETHYLSILYL AZIDE; THEBAINE DERIVATIVES; ORGANIC-SYNTHESIS; NITRILES; MOIETY; ANTAGONISTS; CONVERSION;

D O I：

10.1515/chempap-2015-0124

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The present study on tetrazole compounds, which have a wide area of application, proposes a new, simple and highly effective method. A series of 5-substituted 1H-tetrazoles were synthesised in DMF via the [3 + 2] cycloaddition reaction, in which different aryl nitriles with sodium azide were used and copper( I) chloride served as a catalyst. Short reaction times, high yields and simple procedures rendered this method attractive and useful for the organic synthesis of 5-substituted 1H-tetrazoles. A further advantage was the use of an environmentally friendly catalyst. (C) 2015 Institute of Chemistry, Slovak Academy of Sciences

引用

页码：1231 / 1236

页数：6

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