Asymmetric organocatalytic three-component 1,3-dipolar cycloaddition: Control of stereochemistry via a chiral bronsted acid activated dipole

被引：243

作者：

Chen, Xiao-Hua ^{[1
,2
,3
]}

Zhang, Wen-Quan ^{[1
,2
]}

Gong, Liu-Zhu ^{[1
,2
,3
]}

机构：

[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China

[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China

[3] Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 17期

关键词：

D O I：

10.1021/ja801034e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Bronsted acid catalyzed three-component asymmetric 1,3-dipolar addition reaction between aldehydes, amino esters, and dipolarophiles by a new bisphosphoric acid, derived from the linked BINOL, furnished multiply substituted pyrrolidines in high yield with excellent enantioselectivities under mild conditions.

引用

页码：5652 / +

页数：3

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