Proton beam therapy for posterior pole circumscribed choroidal haemangioma

被引:22
作者
Lee, V
Hungerford, JL [1 ]
机构
[1] St Bartholomews Hosp, Ocular Oncol Serv, London EC1A 7BE, England
[2] Moorfields Eye Hosp, London, England
关键词
charged particle therapy; choroidal haemangioma; proton beam therapy; proton therapy;
D O I
10.1038/eye.1998.240
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Background Macular and juxtapapillary circumscribed choroidal haemangiomas (CCH) have always posed a diagnostic and therapeutic challenge. Proton beam therapy has been advocated by Zografos and associates as optimal for treating these rumours in this critical region as charged particles have a highly localised and uniform dose distribution. Patients We present 3 cases of CCH treated with proton beam therapy. Two patients developed radiation optic neuropathy and maculopathy, and one had a persistent exudative macular detachment following treatment. Conclusion Our experience with proton therapy of these tumours has been disappointing in preventing radiation optic neuropathy and maculopathy and offers little advantage over external irradiation. The majority of our patients with this condition are now treated with low-dose lens-sparing external beam radiotherapy or brachytherapy, which has encouraging visual results and is a far more cost-effective option.
引用
收藏
页码:925 / 928
页数:4
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