Oligometastases revisited

被引：764

作者：

Weichselbaum, Ralph R. ^{[1
]}

Hellman, Samuel ^{[1
]}

机构：

[1] Univ Chicago, Dept Radiat & Cellular Oncol, Ludwig Ctr Metastasis Res, Med Ctr, Chicago, IL 60637 USA

来源：

NATURE REVIEWS CLINICAL ONCOLOGY | 2011年 / 8卷 / 06期

关键词：

COLORECTAL-CARCINOMA METASTASES; STEREOTACTIC BODY RADIOTHERAPY; PANCREATIC-CANCER; RADIATION-THERAPY; HEPATIC RESECTION; LIVER METASTASES; GENE SIGNATURES; BREAST-CANCER; TUMOR; LUNG;

D O I：

10.1038/nrclinonc.2011.44

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We previously proposed a clinical state of metastasis termed 'oligometastases' that refers to restricted tumor metastatic capacity. The implication of this concept is that local cancer treatments are curative in a proportion of patients with metastases. Here we review clinical and laboratory data that support the hypothesis that oligometastasis is a distinct clinical entity. Investigations of the prevalence, mechanism of occurrence, and position in the metastatic cascade, as well as the determination of molecular markers to distinguish oligometastatic from polymetastatic disease, are ongoing.

引用

页码：378 / 382

页数：5

共 41 条

[1] Models, mechanisms and clinical evidence for cancer dormancy [J].

Aguirre-Ghiso, Julio A. .

NATURE REVIEWS CANCER, 2007, 7 (11) :834-846

[2] Using a Bigger Hammer: The Role of Stereotactic Body Radiotherapy in the Management of Oligometastases [J].

Ben-Josef, Edgar ;

Lawrence, Theodore S. .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (10) :1537-1539

[3] The patterns and dynamics of genomic instability in metastatic pancreatic cancer [J].

Campbell, Peter J. ;

Yachida, Shinichi ;

Mudie, Laura J. ;

Stephens, Philip J. ;

Pleasance, Erin D. ;

Stebbings, Lucy A. ;

Morsberger, Laura A. ;

Latimer, Calli ;

McLaren, Stuart ;

Lin, Meng-Lay ;

McBride, David J. ;

Varela, Ignacio ;

Nik-Zainal, Serena A. ;

Leroy, Catherine ;

Jia, Mingming ;

Menzies, Andrew ;

Butler, Adam P. ;

Teague, Jon W. ;

Griffin, Constance A. ;

Burton, John ;

Swerdlow, Harold ;

Quail, Michael A. ;

Stratton, Michael R. ;

Iacobuzio-Donahue, Christine ;

Futreal, P. Andrew .

NATURE, 2010, 467 (7319) :1109-1113

[4]

CHAMBERS AF, 1981, CANCER RES, V41, P1368

[5]

CILLO C, 1987, CANCER RES, V47, P2604

[6] BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution [J].

Deng, CX .

NUCLEIC ACIDS RESEARCH, 2006, 34 (05) :1416-1426

[7] Interferons, immunity and cancer immunoediting [J].

Dunn, Gavin P. ;

Koebel, Catherine M. ;

Schreiber, Robert D. .

NATURE REVIEWS IMMUNOLOGY, 2006, 6 (11) :836-848

[8]

Edge S.B., 2010, AJCC cancer staging manual, V649

[9] RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis (Retracted article. See vol. 579, pg. 456, 2020) [J].

Erler, JT ;

Bennewith, KL ;

Nicolau, M ;

Dornhöfer, N ;

Kong, C ;

Le, QT ;

Chi, JTA ;

Jeffrey, SS ;

Giaccia, AJ .

NATURE, 2006, 440 (7088) :1222-1226

[10] STEREOTACTIC BODY RADIATION THERAPY FOR EARLY-STAGE NON-SMALL-CELL LUNG CARCINOMA: FOUR-YEAR RESULTS OF A PROSPECTIVE PHASE II STUDY [J].

Fakiris, Achilles J. ;

McGarry, Ronald C. ;

Yiannoutsos, Constantin T. ;

Papiez, Lech ;

Williams, Mark ;

Henderson, Mark A. ;

Timmerman, Robert .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2009, 75 (03) :677-682

← 1 2 3 4 5 →