RGD conjugated, Cy5.5 labeled polyamidoamine dendrimers for targeted near-infrared fluorescence imaging of esophageal squamous cell carcinoma

被引：14

作者：

Li, Qi ^{[1
]}

Gu, Wei ^{[2
]}

Liu, Kang ^{[2
]}

Xiao, Ning ^{[3
]}

Zhang, Juan ^{[2
]}

Shao, Linlin ^{[1
]}

Li, Lei ^{[4
]}

Zhang, Shutian ^{[1
]}

Li, Peng ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Key Lab Precancerous Les Digest Dis, Beijing Friendship Hosp,Dept Gastroenterol, Beijing Digest Dis Ctr,Natl Clin Res Ctr Digest D, Beijing, Peoples R China

[2] Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Beijing, Peoples R China

[3] Capital Med Univ, Beijing Tongren Hosp, Dept Pharm, Beijing, Peoples R China

[4] Weifang Med Univ, Affiliated Hosp, Dept Gastroenterol, Weifang, Peoples R China

来源：

RSC ADVANCES | 2016年 / 6卷 / 78期

基金：

中国国家自然科学基金;

关键词：

IN-VIVO; CANCER; NANOPARTICLES; DELIVERY; THERAPY; FOLATE; PROBE; MICE;

D O I：

10.1039/c6ra12927g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The early detection of esophageal squamous cell carcinoma (ESCC), one of the most common human neoplasms, is of great importance in improving prognosis. However, there is a lack of screening methods with high sensitivity for early diagnosis of ESCC. In this study, we developed a alpha v beta 3 integrin targeted near-infrared (NIR) fluorescence nanoprobe by conjugation of NIR dye Cy5.5 and tumor vasculature targeted cyclic RGDfK peptide onto a polyamidoamine (PAMAM) dendrimer (RGD-PEG-PAMAM-Cy5.5). The applicability of the as-prepared targeted nanoprobe for NIR fluorescence imaging of 4-NQO induced large and tiny esophageal neoplasms in mice was examined. It was demonstrated that the NIR fluorescence imaging with our targeted nanoprobe enables the identification of ESCC at an early stage.

引用

页码：74560 / 74566

页数：7

共 28 条

[11] Dendrimer as nanocarrier for drug delivery [J].

Kesharwani, Prashant ;

Jain, Keerti ;

Jain, Narendra Kumar .

PROGRESS IN POLYMER SCIENCE, 2014, 39 (02) :268-307

[12] Screening for oesophageal cancer [J].

Lao-Sirieix, Pierre ;

Fitzgerald, Rebecca C. .

NATURE REVIEWS CLINICAL ONCOLOGY, 2012, 9 (05) :278-287

[13] A high-performance imaging probe with NIR luminescence and synergistically enhanced T1-T2 relaxivity for in vivo hepatic tumor targeting and multimodal imaging [J].

Liu, Jian ;

Li, Zhengzheng ;

Yang, Xiangliang ;

Liu, Weisheng ;

Wang, Baodui ;

Zhu, Yanhong ;

Mu, Ketao ;

Zhu, Wenzhen .

CHEMICAL COMMUNICATIONS, 2015, 51 (69) :13369-13372

[14] Oesophageal carcinoma [J].

Pennathur, Arjun ;

Gibson, Michael K. ;

Jobe, Blair A. ;

Luketich, James D. .

LANCET, 2013, 381 (9864) :400-412

[15] Esophagectomy for T1 Esophageal Cancer: Outcomes in 100 Patients and Implications for Endoscopic Therapy [J].

Pennathur, Arjun ;

Farkas, Andrew ;

Krasinskas, Alyssa M. ;

Ferson, Peter F. ;

Gooding, William E. ;

Michael, K. Gibson ;

Schuchert, Matthew J. ;

Landreneau, Rodney J. ;

Luketich, James D. .

ANNALS OF THORACIC SURGERY, 2009, 87 (04) :1048-1055

[16] Dendrimer-based molecular imaging contrast agents [J].

Qiao, Zheng ;

Shi, Xiangyang .

PROGRESS IN POLYMER SCIENCE, 2015, 44 :1-27

[17] Fluorescence imaging in vivo:: recent advances [J].

Rao, Jianghong ;

Dragulescu-Andrasi, Anca ;

Yao, Hequan ;

Yao, Hequan .

CURRENT OPINION IN BIOTECHNOLOGY, 2007, 18 (01) :17-25

[18] In Vivo Chemistry for Pretargeted Tumor Imaging in Live Mice [J].

Rossin, Raffaella ;

Verkerk, Pascal Renart ;

van den Bosch, Sandra M. ;

Vulders, Roland C. M. ;

Verel, Iris ;

Lub, Johan ;

Robillard, Marc S. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (19) :3375-3378

[19] Multifunctional Gadolinium-Doped Manganese Carbonate Nanoparticles for Targeted MR/Fluorescence Imaging of Tiny Brain Gliomas [J].

Shao, Chen ;

Li, Shuai ;

Gu, Wei ;

Gong, Ningqiang ;

Zhang, Juan ;

Chen, Ning ;

Shi, Xiangyang ;

Ye, Ling .

ANALYTICAL CHEMISTRY, 2015, 87 (12) :6251-6257

[20] Nanoparticles for bioimaging [J].

Sharma, Parvesh ;

Brown, Scott ;

Walter, Glenn ;

Santra, Swadeshmukul ;

Moudgil, Brij .

ADVANCES IN COLLOID AND INTERFACE SCIENCE, 2006, 123 (471-485) :471-485

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