RGD conjugated, Cy5.5 labeled polyamidoamine dendrimers for targeted near-infrared fluorescence imaging of esophageal squamous cell carcinoma

被引：14

作者：

Li, Qi ^{[1
]}

Gu, Wei ^{[2
]}

Liu, Kang ^{[2
]}

Xiao, Ning ^{[3
]}

Zhang, Juan ^{[2
]}

Shao, Linlin ^{[1
]}

Li, Lei ^{[4
]}

Zhang, Shutian ^{[1
]}

Li, Peng ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Key Lab Precancerous Les Digest Dis, Beijing Friendship Hosp,Dept Gastroenterol, Beijing Digest Dis Ctr,Natl Clin Res Ctr Digest D, Beijing, Peoples R China

[2] Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Beijing, Peoples R China

[3] Capital Med Univ, Beijing Tongren Hosp, Dept Pharm, Beijing, Peoples R China

[4] Weifang Med Univ, Affiliated Hosp, Dept Gastroenterol, Weifang, Peoples R China

来源：

RSC ADVANCES | 2016年 / 6卷 / 78期

基金：

中国国家自然科学基金;

关键词：

IN-VIVO; CANCER; NANOPARTICLES; DELIVERY; THERAPY; FOLATE; PROBE; MICE;

D O I：

10.1039/c6ra12927g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The early detection of esophageal squamous cell carcinoma (ESCC), one of the most common human neoplasms, is of great importance in improving prognosis. However, there is a lack of screening methods with high sensitivity for early diagnosis of ESCC. In this study, we developed a alpha v beta 3 integrin targeted near-infrared (NIR) fluorescence nanoprobe by conjugation of NIR dye Cy5.5 and tumor vasculature targeted cyclic RGDfK peptide onto a polyamidoamine (PAMAM) dendrimer (RGD-PEG-PAMAM-Cy5.5). The applicability of the as-prepared targeted nanoprobe for NIR fluorescence imaging of 4-NQO induced large and tiny esophageal neoplasms in mice was examined. It was demonstrated that the NIR fluorescence imaging with our targeted nanoprobe enables the identification of ESCC at an early stage.

引用

页码：74560 / 74566

页数：7

共 28 条

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