Discovery of BILN 2061 -: A small molecule inhibitor of the hepatitis C virus serine protease.

被引:0
|
作者
Llinàs-Brunet, M [1 ]
Bailey, M [1 ]
Bolger, G [1 ]
Cameron, D [1 ]
Cartier, M [1 ]
Faucher, AM [1 ]
Goudreau, N [1 ]
Kukolj, G [1 ]
Lagacé, L [1 ]
Pause, A [1 ]
Rancourt, J [1 ]
Thibeault, D [1 ]
Tsantrizos, Y [1 ]
Lamarre, D [1 ]
机构
[1] Boehringer Ingelheim Canada Ltd, Res & Dev, Laval, PQ H7S 2G5, Canada
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
320-MEDI
引用
收藏
页码:U231 / U231
页数:1
相关论文
共 50 条
  • [1] The discovery of BILN 2061 - An orally bioavailable small molecule inhibitor of the HCV serine protease and a promising antiviral for treatment of hepatitis C.
    Lamarre, D
    Bailey, M
    Bolger, G
    Cameron, D
    Cartier, M
    Faucher, AM
    Goudreau, N
    Kukolj, G
    Lagace, L
    Pause, A
    Rancourt, J
    Thibeault, D
    Tsantrizos, Y
    Llinas-Brunet, M
    HEPATOLOGY, 2002, 36 (04) : 279A - 279A
  • [2] BILN 2061 ZW -: an orally bioavailable small molecule inhibitor of the HCV serine protease and a promising antiviral for treatment of hepatitis C
    Lamarre, D
    Bailey, M
    Bolger, G
    Cameron, D
    Cartier, M
    Faucher, AM
    Goudreau, N
    Kukolj, G
    Lagacé, L
    Pause, A
    Rancourt, J
    Thibeault, D
    Tsantrizos, Y
    Llinàs-Brunet, M
    ANTIVIRAL THERAPY, 2002, 7 (04) : L101 - L101
  • [3] Viral kinetics in patients with chronic hepatitis C treated with the serine protease inhibitor BILN 2061
    Herrmann, Eva
    Zeuzem, Stefan
    Sarrazin, Christoph
    Hinrichsen, Holger
    Benhamou, Yves
    Manns, Michael P.
    Reiser, Markus
    Reesink, Henk
    Calleja, Jose L.
    Forns, Xavier
    Steinmann, Gerhard G.
    Nehmiz, Gerhard
    ANTIVIRAL THERAPY, 2006, 11 (03) : 371 - 376
  • [4] Short-term antiviral efficacy of BILN 2061, a hepatitis C virus serine protease inhibitor, in hepatitis C genotype 1 patients
    Hinrichsen, H
    Benhamou, Y
    Wedemeyer, H
    Reiser, M
    Sentjens, RE
    Calleja, JL
    Forns, X
    Erhardt, A
    Crönlein, J
    Chaves, RL
    Yong, CL
    Nehmiz, G
    Steinmann, GG
    GASTROENTEROLOGY, 2004, 127 (05) : 1347 - 1355
  • [5] Hepatitis C viral kinetics in chronically infected patients treated with the serine protease inhibitor BILN 2061
    Herrmann, E
    Zeuzem, S
    Sarrazin, C
    Hinrichsen, H
    Benhamou, Y
    Wedemeyer, H
    Steinmann, G
    Nehmiz, G
    JOURNAL OF HEPATOLOGY, 2004, 40 : 24 - 25
  • [6] Mechanism of drug resistance in hepatitis C: The case of protease inhibitor BILN-2061
    Courcambeck, J
    Perbost, R
    Chabaud, P
    Pepe, G
    Bouzidi, M
    Mabrouk, K
    Sabatier, JM
    Halfon, P
    Jouirou, B
    JOURNAL OF HEPATOLOGY, 2005, 42 : 104 - 105
  • [7] Tripeptide inhibitors of the hepatitis C virus serine protease.
    Ghiro, E
    Bailey, M
    Gorys, V
    Goudreau, N
    Halmos, T
    Poirier, M
    Rancourt, J
    Llinàs-Brunet, M
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U932 - U932
  • [8] Small peptide-based inhibitors of the hepatitis C virus serine protease.
    Narjes, F
    Colarusso, S
    Gerlach, B
    Koehler, K
    Koch, U
    Steinkühler, C
    Bazzo, R
    Sollazzo, M
    Altamura, S
    De Francesco, R
    Matassa, VG
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 220 : U539 - U540
  • [9] Discovery of novel tri-peptide inhibitors of the hepatitis C virus serine protease.
    Llinas-Brunet, M
    Bailey, M
    Bordeleau, J
    Brochu, C
    Cameron, D
    Cartier, M
    Duceppe, JS
    Faucher, AM
    Fazal, G
    Ghiro, E
    Gorys, V
    Goudreau, N
    Goulet, S
    Grand-Maître, C
    Halmos, T
    LaPlante, S
    Marquis, M
    Maurice, R
    Nar, H
    Poirier, M
    Poupart, MA
    Simoneau, B
    Rancourt, J
    Thibeault, D
    Tsantrizos, Y
    Wernic, D
    Lamarre, D
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 220 : U540 - U540
  • [10] Sensitivity of NS3 serine proteases from hepatitis C virus genotypes 2 and 3 to the inhibitor BILN 2061
    Thibeault, D
    Bousquet, C
    Gingras, R
    Lagacé, L
    Maurice, R
    White, PW
    Lamarre, D
    JOURNAL OF VIROLOGY, 2004, 78 (14) : 7352 - 7359