Structural features of the legume lectins

被引：20

作者：

Hamelryck, TW ^{[1
]}

Loris, R ^{[1
]}

Bouckaert, J ^{[1
]}

Wyns, L ^{[1
]}

机构：

[1] Free Univ Brussels VIB, Lab Ultrastruct, B-1640 Rhode St Genese, Belgium

来源：

TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY | 1998年 / 10卷 / 55期

关键词：

lectin-like proteins; legume lectins; protein-sugar interactions; quaternary structure; x-ray crystallography;

D O I：

10.4052/tigg.10.349

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The legume lectins are a family of carbohydrate binding proteins found in the Leguminosae plants and are used as a model system for studying protein-carbohydrate interactions. The different legume lectins show a remarkable range of sugar specificities, despite the high sequential and structural similarity of their subunits. Moreover, their subunits can associate into a number of different multimers. The unique variability of quaternary structure has implications for the formation of cross-linked lattices and binding of hydrophobic ligands.

引用

页码：349 / 360

页数：12

共 82 条

[1] CRYSTAL-STRUCTURE OF PEANUT LECTIN, A PROTEIN WITH AN UNUSUAL QUATERNARY STRUCTURE [J].

BANERJEE, R ;

MANDE, SC ;

GANESH, V ;

DAS, K ;

DHANARAJ, V ;

MAHANTA, SK ;

SUGUNA, K ;

SUROLIA, A ;

VIJAYAN, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (01) :227-231

[2] Conformation, protein-carbohydrate interactions and a novel subunit association in the refined structure of peanut lectin-lactose complex [J].

Banerjee, R ;

Das, K ;

Ravishankar, R ;

Suguna, K ;

Surolia, A ;

Vijayan, M .

JOURNAL OF MOLECULAR BIOLOGY, 1996, 259 (02) :281-296

[3]

BECKER JW, 1975, J BIOL CHEM, V250, P1513

[4] Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation [J].

Bertrand, JA ;

Pignol, D ;

Bernard, JP ;

Verdier, JM ;

Dagorn, JC ;

FontecillaCamps, JC .

EMBO JOURNAL, 1996, 15 (11) :2678-2684

[5]

BHATTACHARYYA L, 1989, J BIOL CHEM, V264, P11543

[6] Substrate mimicry in the active center of a mammalian alpha-amylase: Structural analysis of an enzyme-inhibitor complex [J].

BompardGilles, C ;

Rousseau, P ;

Rouge, P ;

Payan, F .

STRUCTURE, 1996, 4 (12) :1441-1452

[7] Crystallographic structure of metal-free concanavalin A at 2.5 angstrom resolution [J].

Bouckaert, J ;

Loris, R ;

Poortmans, F ;

Wyns, L .

PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1995, 23 (04) :510-524

[8]

BOUCKAERT J, 1996, VAN DRIESSCHE, P50

[9]

BOURNE Y, 1994, J BIOL CHEM, V269, P9429

[10] 3-DIMENSIONAL STRUCTURES OF COMPLEXES OF LATHYRUS-OCHRUS ISOLECTIN-I WITH GLUCOSE AND MANNOSE - FINE SPECIFICITY OF THE MONOSACCHARIDE-BINDING SITE [J].

BOURNE, Y ;

ROUSSEL, A ;

FREY, M ;

ROUGE, P ;

FONTECILLACAMPS, JC ;

CAMBILLAU, C .

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 1990, 8 (04) :365-376

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