Allosteric properties of hemoglobin and the plasma membrane of the erythrocyte: New insights in gas transport and metabolic modulation

被引：29

作者：

De Rosa, Maria Cristina ^{[1
]}

Carelli Alinovi, Cristiana ^{[1
]}

Galtieri, Antonio ^{[2
]}

Russo, Annamaria ^{[2
]}

Giardina, Bruno ^{[1
]}

机构：

[1] Catholic Univ, Inst Chem Mol Recognit, CNR, Inst Biochem& Clin Biochem, I-00168 Rome, Italy

[2] Univ Messina, Dept Organ & Biol Chem, Messina, Italy

来源：

IUBMB LIFE | 2008年 / 60卷 / 02期

关键词：

red blood cells; nitric oxide; 2,3-DPG; band; 3; glycolysis;

D O I：

10.1002/iub.15

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Within the red blood cell the hemoglobin molecule is subjected to modulation mechanisms, namely homo- and heterotropic interactions, which optimize its functional behavior to the specific physiological requirements. At the cellular level, these modulation mechanisms are utilized to perform a number of other functions that are not minor with respect to the basic function of oxygen transport. Here we report some key examples concerning: (i) the interaction of hemoglobin with band 3 and its influence on glucose metabolism; (ii) the role of the ligand-linked quaternary transition of hemoglobin in the control of "NO bioactivity" and of gas diffusion; (iii) the interaction of plasma membrane with the various oxidative derivatives of the hemoglobin molecule. (c) 2008 IUBMB.

引用

页码：87 / 93

页数：7

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