Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike

被引：211

作者：

Yamasoba, Daichi ^{[1
,2
]}

Kimura, Izumi ^{[1
]}

Nasser, Hesham ^{[3
,4
]}

Morioka, Yuhei ^{[5
]}

Nao, Naganor ^{[6
,7
]}

Ito, Jumpei ^{[1
]}

Uriu, Keiya ^{[1
,8
]}

Tsuda, Masumi ^{[9
,10
]}

Zahradnik, Jiri ^{[11
]}

Shirakawa, Kotaro ^{[12
]}

Suzuki, Rigel ^{[5
]}

Kishimoto, Mai ^{[13
]}

Kosugi, Yusuke ^{[1
,14
,15
]}

Kobiyama, Kouji ^{[16
,17
]}

Hara, Teppei ^{[16
]}

Toyoda, Mako ^{[18
]}

Tanaka, Yuri L. ^{[19
]}

Butlertanaka, Erika P. ^{[19
]}

Shimizu, Ryo ^{[3
]}

Ito, Hayato ^{[5
]}

Wang, Lei ^{[9
,10
]}

Oda, Yoshitaka ^{[9
]}

Orba, Yasuko ^{[13
,19
]}

Sasaki, Michihito ^{[13
,20
]}

Nagata, Kayoko ^{[12
]}

Yoshimatsu, Kumiko ^{[21
]}

Asakura, Hiroyuki ^{[22
]}

Nagashima, Mami ^{[22
]}

Sadamasu, Kenji ^{[22
]}

Yoshimura, Kazuhisa ^{[22
]}

Kuramochi, Jin ^{[23
]}

Seki, Motoaki ^{[24
]}

Fujiki, Ryoji ^{[24
]}

Kaneda, Atsushi ^{[24
]}

Shimada, Tadanaga ^{[25
]}

Nakada, Taka-aki ^{[25
]}

Sakao, Seiichiro ^{[26
]}

Suzuki, Takuji ^{[26
]}

Ueno, Takamasa ^{[18
]}

Takaori-Kondo, Akifumi ^{[12
]}

Ishii, Ken J. ^{[16
,17
]}

Schreiber, Gideon ^{[11
]}

Sawa, Hirofumi ^{[6
,7
,13
,20
]}

Saito, Akatsuki ^{[19
,27
,28
]}

Irie, Takashi ^{[29
]}

Tanaka, Shinya ^{[9
,10
]}

Matsuno, Keita ^{[7
,20
,30
]}

Fukuhara, Takasuke ^{[5
]}

Ikeda, Terumasa ^{[3
]}

Sato, Kei ^{[1
,8
,17
,31
,32
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Div Syst Virol, Dept Microbiol & Immunol, Tokyo, Japan

[2] Kobe Univ, Fac Med, Kobe, Hyogo, Japan

[3] Kumamoto Univ, Div Mol Virol & Genet, Joint Res Ctr Human Retrovirus Infect, Kumamoto, Japan

[4] Suez Canal Univ, Dept Clin Pathol, Fac Med, Ismailia, Egypt

[5] Hokkaido Univ, Grad Sch Med, Dept Microbiol & Immunol, Sapporo, Hokkaido, Japan

[6] Hokkaido Univ, Int Inst Zoonosis Control, Div Int Res Promot, Sapporo, Hokkaido, Japan

[7] Hokkaido Univ, One Hlth Res Ctr, Sapporo, Hokkaido, Japan

[8] Univ Tokyo, Grad Sch Med, Tokyo, Japan

[9] Hokkaido Univ, Dept Canc Pathol, Fac Med, Sapporo, Hokkaido, Japan

[10] Hokkaido Univ, Inst Chem React Design & Discovery WPI ICReDD, Sapporo, Hokkaido, Japan

[11] Weizmann Inst Sci, Dept Biomol Sci, Rehovot, Israel

[12] Kyoto Univ, Grad Sch Med, Dept Hematol & Oncol, Kyoto, Japan

[13] Hokkaido Univ, Int Inst Zoonosis Control, Div Mol Pathobiol, Sapporo, Hokkaido, Japan

[14] Kyoto Univ, Inst Frontier Life & Med Sci, Lab Syst Virol, Kyoto, Japan

[15] Kyoto Univ, Grad Sch Pharmaceut Sci, Kyoto, Japan

[16] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Vaccine Sci, Tokyo, Japan

[17] Univ Tokyo, Inst Med Sci, Int Vaccine Design Ctr, Tokyo, Japan

[18] Kumamoto Univ, Joint Res Ctr Human Retrovirus Infect, Div Infect & Immun, Kumamoto, Japan

[19] Univ Miyazaki, Dept Vet Sci, Fac Agr, Miyazaki, Japan

[20] Hokkaido Univ, Int Inst Zoonosis Control, Int Collaborat Unit, Sapporo, Hokkaido, Japan

[21] Hokkaido Univ, Inst Genet Med, Sapporo, Hokkaido, Japan

[22] Tokyo Metropolitan Inst Publ Hlth, Tokyo, Japan

[23] Interpk Kuramochi Clin, Utsunomiya, Tochigi, Japan

[24] Chiba Univ, Grad Sch Med, Dept Mol Oncol, Chiba, Japan

[25] Chiba Univ, Grad Sch Med, Dept Emergency & Crit Care Med, Chiba, Japan

[26] Chiba Univ, Grad Sch Med, Dept Respirol, Chiba, Japan

[27] Univ Miyazaki, Ctr Anim Dis Control, Chiba, Japan

[28] Univ Miyazaki, Grad Sch Med & Vet Med, Miyazaki, Japan

[29] Hiroshima Univ, Inst Biomed & Hlth Sci, Hiroshima, Japan

[30] Hokkaido Univ, Int Inst Zoonosis Control, Div Risk Anal & Management, Sapporo, Hokkaido, Japan

[31] Univ Tokyo, Inst Med Sci, Int Res Ctr Infect Dis, Tokyo, Japan

[32] Japan Sci & Technol Agcy, CREST, Kawaguchi, Saitama, Japan

来源：

CELL | 2022年 / 185卷 / 12期

关键词：

VARIANT; L452R; TOOL;

D O I：

10.1016/j.cell.2022.04.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Soon after the emergence and global spread of the SARS-CoV-2 Omicron lineage BA.1, another Omicron lineage, BA.2, began outcompeting BA.1. The results of statistical analysis showed that the effective reproduction number of BA.2 is 1.4-fold higher than that of BA.1. Neutralization experiments revealed that immunity induced by COVID vaccines widely administered to human populations is not effective against BA.2, similar to BA.1, and that the antigenicity of BA.2 is notably different from that of BA.1. Cell culture experiments showed that the BA.2 spike confers higher replication efficacy in human nasal epithelial cells and is more efficient in mediating syncytia formation than the BA.1 spike. Furthermore, infection experiments using hamsters indicated that the BA.2 spike-bearing virus is more pathogenic than the BA.1 spike-bearing virus. Altogether, the results of our multiscale investigations suggest that the risk of BA.2 to global health is potentially higher than that of BA.1.

引用

页码：2103 / +

页数：33

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