caspase;
cathepsin;
B cell receptor;
apoptosis;
inhibitor;
D O I:
10.1016/S0014-5793(03)00966-9
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Crosslinking of the WEHI 231 lymphoma B cell receptor (BCR) leads to growth arrest followed by apoptosis. In a study of the role of lysosomal cysteine proteinases in BCR-mediated apoptosis we provide evidence that commitment to apoptosis correlates with a time-dependent increase in caspase and cathepsin activities. We also show that activation of cathepsins is a caspase-independent process, and caspase cascade activation is independent of lysosomal endopeptidases. BCR-induced nuclear fragmentation was not prevented, but rather delayed in the absence of detectable caspase and cathepsin activities, suggesting that BCR-driven apoptosis of these cells may use an alternative proteolytic mechanism independent of caspases and cathepsins. (C) 2003 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
机构:
Mayo Clin & Mayo Fdn, Sch Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Sch Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA
Guicciardi, ME
Miyoshi, H
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin & Mayo Fdn, Sch Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Sch Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA
Miyoshi, H
Bronk, SF
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin & Mayo Fdn, Sch Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Sch Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA
Bronk, SF
Gores, GJ
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin & Mayo Fdn, Sch Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Sch Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA
机构:
Mayo Clin & Mayo Fdn, Sch Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Sch Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA
Guicciardi, ME
Miyoshi, H
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin & Mayo Fdn, Sch Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Sch Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA
Miyoshi, H
Bronk, SF
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin & Mayo Fdn, Sch Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Sch Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA
Bronk, SF
Gores, GJ
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin & Mayo Fdn, Sch Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USAMayo Clin & Mayo Fdn, Sch Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA