Advances in Hyaluronic-Acid-Based (Nano)Devices for Cancer Therapy

被引：40

作者：

Della Sala, Francesca ^{[1
]}

Fabozzi, Antonio ^{[2
]}

di Gennaro, Mario ^{[1
]}

Nuzzo, Stefano ^{[2
]}

Makvandi, Pooyan ^{[1
]}

Solimando, Nicola ^{[2
]}

Pagliuca, Maurizio ^{[2
]}

Borzacchiello, Assunta ^{[1
]}

机构：

[1] CNR, Natl Res Council, IPCB, Inst Polymers Composites & Biomat, Viale JF Kennedy 54, I-80125 Naples, Italy

[2] Altergon Italia Srl, I-83040 Morra De Sanctis, AV, Italy

来源：

MACROMOLECULAR BIOSCIENCE | 2022年 / 22卷 / 01期

关键词：

cancer therapy; cell internalization; functionalization; hyaluronic acid; surface modifications; DRUG-DELIVERY; TARGETED DELIVERY; IN-VITRO; CHITOSAN NANOPARTICLES; MOLECULAR-WEIGHT; GRAPHENE OXIDE; RESPONSIVE NANOPARTICLES; POLYMERIC NANOPARTICLES; INTRACELLULAR DELIVERY; HYBRID NANOPARTICLES;

D O I：

10.1002/mabi.202100304

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer is the main cause of fatality all over the world with a considerable growth rate. Many biologically active nanoplatforms are exploited for tumor treatment. Of nanodevices, hyaluronic acid (HA)-based systems have shown to be promising candidates for cancer therapy due to their high biocompatibility and cell internalization. Herein, surface functionalization of different nanoparticles (NPs), e.g., organic- and inorganic-based NPs, is highlighted. Subsequently, HA-based nanostructures and their applications in cancer therapy are presented.

引用

页数：20

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