Synthesis of novel 5-fluorouracil derivatives containing amino acid Schiff base and their antitumor activities

In order to search for novel high activity and low toxicity antitumor drugs, thirteen novel 5-fluorouracil derivatives containing amino acid Schiff base were synthesized via the condensation reactions of N-1-(2-furanidyl)-N-3-(4-bromobutyl)-5-fluorouracil and amino acid Schiff bases. The structures of the products were confirmed by IR, H-1 NMR, NIS spectra and elemental analyses. The result of preliminary bioassay shows that the new compounds possess antitumor activities to some extent.