Growth Hormone and Aging: Updated Review

被引:76
作者
Bartke, Andrzej [1 ]
机构
[1] Southern Illinois Univ, Dept Internal Med, Sch Med, 801 N,Rutledge St,POB 19628, Springfield, IL 62794 USA
关键词
Aging; Growth hormone; Healthy aging; Life expectancy; Somatotropin; EXTENDS LIFE-SPAN; LONG-LIVED GHRKO; AMES DWARF MICE; FACTOR-I LEVELS; BODY-COMPOSITION; RESISTANCE EXERCISE; REPLACEMENT THERAPY; RECEPTOR DEFICIENCY; MUSCLE STRENGTH; GENE-EXPRESSION;
D O I
10.5534/wjmh.180018
中图分类号
R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
摘要
Role of growth hormone (GH) in mammalian aging is actively explored in clinical, epidemiological, and experimental studies. The age-related decline in GH levels is variously interpreted as a symptom of neuroendocrine aging, as one of causes of altered body composition and other unwelcome symptoms of aging, or as a mechanism of natural protection from cancer and other chronic diseases. Absence of GH signals due to mutations affecting anterior pituitary development, GH secretion, or GH receptors produces an impressive extension of longevity in laboratory mice. Extension of healthspan in these animals and analysis of survival curves suggest that in the absence of GH, aging is slowed down or delayed. The corresponding endocrine syndromes in the human have no consistent impact on longevity, but are associated with remarkable protection from age-related disease. Moreover, survival to extremely old age has been associated with reduced somatotropic (GH and insulin-like growth factor-1) signaling in women and men. In both humans and mice, elevation of GH levels into the supranormal (pathological) range is associated with increased disease risks and reduced life expectancy likely representing acceleration of aging. The widely advertised potential of GH as an anti-aging agent attracted much interest. However, results obtained thus far have been disappointing with few documented benefits and many troublesome side effects. Possible utility of GH in the treatment of sarcopenia and frailty remains to be explored.
引用
收藏
页码:19 / 30
页数:12
相关论文
共 50 条
[41]   The promise of growth hormone in sport: doped or duped [J].
Ho, Ken K. Y. .
ARCHIVES OF ENDOCRINOLOGY METABOLISM, 2019, 63 (06) :576-581
[42]   EFFECTS OF GROWTH-HORMONE AND THYROXINE ON THYMULIN SECRETION IN AGING RATS [J].
GOYA, RG ;
GAGNERAULT, MC ;
SOSA, YE ;
BEVILACQUA, JA ;
DARDENNE, M .
NEUROENDOCRINOLOGY, 1993, 58 (03) :338-343
[43]   Cardiological aging in SAM model: effect of chronic treatment with growth hormone [J].
K. Forman ;
E. Vara ;
C. García ;
C. Ariznavarreta ;
G. Escames ;
J. A. F. Tresguerres .
Biogerontology, 2010, 11 :275-286
[44]   Elements in the pathophysiology of diminished growth hormone (GH) secretion in aging humans [J].
Johannes D. Veldhuis ;
Ali Iranmanesh ;
Arthur Weltman .
Endocrine, 1997, 7 :41-48
[45]   DYNAMICS OF GROWTH-HORMONE RESPONSIVENESS TO GROWTH-HORMONE RELEASING-FACTOR IN AGING RATS - PERIPHERAL AND CENTRAL INFLUENCES [J].
DESLAURIERS, N ;
GAUDREAU, P ;
ABRIBAT, T ;
RENIER, G ;
PETITCLERC, D ;
BRAZEAU, P .
NEUROENDOCRINOLOGY, 1991, 53 (05) :439-446
[46]   ASPECTS OF THE NEUROENDOCRINE CONTROL OF GROWTH-HORMONE SECRETION IN AGING MAMMALS [J].
MULLER, EE ;
CELLA, SG ;
COLONNA, VD ;
PARENTI, M ;
COCCHI, D ;
LOCATELLI, V .
JOURNAL OF REPRODUCTION AND FERTILITY, 1993, :99-114
[47]   Does growth hormone prevent or accelerate aging? [J].
Bartke, A ;
Brown-Borg, HM ;
Bode, AM ;
Carlson, J ;
Hunter, WS ;
Bronson, RT .
EXPERIMENTAL GERONTOLOGY, 1998, 33 (7-8) :675-687
[48]   Growth hormone (GH)-releasing hormone and GH secretagogues in normal aging: Fountain of Youth or Pool of Tantalus? [J].
Hersch, Elizabeth C. ;
Merriam, George R. .
CLINICAL INTERVENTIONS IN AGING, 2008, 3 (01) :121-129
[49]   Biological effects of recombinant human growth hormone therapy on metabolism in children with growth hormone deficiency: a review [J].
Dyrka, Kamil ;
Lachut, Kamila ;
Kolesinska, Zofia ;
Niedziela, Marek ;
Obara-Moszynska, Monika .
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 2025, 38 (08) :796-806
[50]   Growth Hormone Administration: Is It Safe and Effective for Athletic Performance [J].
Birzniece, Vita ;
Nelson, Anne E. ;
Ho, Ken K. Y. .
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2010, 39 (01) :11-+