Maternal uterine natural killer cells nurture fetal growth: in medio stat virtus

被引：31

作者：

Colucci, Francesco ^{[1
]}

Kieckbusch, Jens

机构：

[1] Univ Cambridge, Ctr Trophoblast Res, Cambridge CB2 0SW, England

来源：

TRENDS IN MOLECULAR MEDICINE | 2015年 / 21卷 / 02期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

uterine natural killer cells; maternal tolerance; fetal growth; allorecognition; REGULATORY T-CELLS; LOW-BIRTH-WEIGHT; NK CELLS; IMMUNOLOGICAL PARADOX; TROPHOBLAST CELLS; PREGNANCY; RECEPTORS; DIFFERENTIATION; EXPRESSION; DISEASE;

D O I：

10.1016/j.molmed.2014.12.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Much research in reproductive immunology is preoccupied with maternal tolerance of the semi-allogeneic fetus. This inevitably leads to the assumption that the maternal immune system should be suppressed, similarly to the immunosuppression needed to avoid rejection of an allograft. However, the parallels with transplantation immunology are misleading, and we discuss how interactions between variable immune system genes expressed on maternal natural killer (NK) cells and on the fetal trophoblast modulate fetal growth. Exaggerated suppression or activation of maternal NK cells associates with both extremes of birth weight.

引用

页码：60 / 67

页数：8

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