Optical heterodyne surface plasmon resonance biosensor

被引：0

作者：

Chou, C ^{[1
]}

Kuo, WC ^{[1
]}

Wu, HT ^{[1
]}

机构：

[1] Natl Yang Ming Univ, Inst Radiol Sci, Taipei 112, Taiwan

来源：

OPTICAL FIBERS AND SENSORS FOR MEDICAL APPLICATIONS III | 2003年 / 4957卷

关键词：

surface plasma wave (SPW); surface plasmon resonance (SPR); biosensor; optical heterodyne;

D O I：

10.1117/12.476721

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A novel optical heterodyne surface plasmon resonance (SPR) biosensor using Zeeman laser is proposed. There are two surface plasma waves (SPWs) being excited by two correlated P polarized waves in an SPR device of Kretschmann configuration. The two reflected P waves are optically heterodyned so that. the magnitude of the heterodyned signal is proportional to the multiplication of two attenuated reflected P waves. Then the detection sensitivity and the dynamical range based on this amplitude sensitive method are enhanced. In the experiment, the kinetics between mouse IgG and anti-mouse IgG is obtained according to the sensograms of, different concentrations of anti-mouse IgG The detection sensitivity corresponding to 0.2 nM is achieved. In addition, a concentration of 5 ng/ml of protein G interacting with mouse IgG is measured successfully.

引用

页码：149 / 156

页数：8

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