Optical heterodyne surface plasmon resonance biosensor

被引：0
|
作者：
Chou, C [1 ]
Kuo, WC [1 ]
Wu, HT [1 ]
机构：
[1] Natl Yang Ming Univ, Inst Radiol Sci, Taipei 112, Taiwan
来源：
OPTICAL FIBERS AND SENSORS FOR MEDICAL APPLICATIONS III | 2003年 / 4957卷
关键词：
surface plasma wave (SPW); surface plasmon resonance (SPR); biosensor; optical heterodyne;
D O I：
10.1117/12.476721
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
A novel optical heterodyne surface plasmon resonance (SPR) biosensor using Zeeman laser is proposed. There are two surface plasma waves (SPWs) being excited by two correlated P polarized waves in an SPR device of Kretschmann configuration. The two reflected P waves are optically heterodyned so that. the magnitude of the heterodyned signal is proportional to the multiplication of two attenuated reflected P waves. Then the detection sensitivity and the dynamical range based on this amplitude sensitive method are enhanced. In the experiment, the kinetics between mouse IgG and anti-mouse IgG is obtained according to the sensograms of, different concentrations of anti-mouse IgG The detection sensitivity corresponding to 0.2 nM is achieved. In addition, a concentration of 5 ng/ml of protein G interacting with mouse IgG is measured successfully.
引用
收藏
页码：149 / 156
页数：8
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