Clinical outcomes of head and neck cancer patients who refuse curative therapy in pursuit of alternative medicine

被引：5
作者：
Balogh, Lauren C. [1 ,2 ]
Matthews, T. Wayne [1 ,3 ,4 ]
Schrag, Christiaan [1 ,2 ]
Elebro, Karin A. [1 ,2 ,5 ,6 ]
机构：
[1] Alberta Hlth Serv, Foothills Med Ctr, Calgary, AB, Canada
[2] Univ Calgary, Cumming Sch Med, Dept Surg, Sect Plast & Reconstruct Surg, Calgary, AB, Canada
[3] Univ Calgary, Cumming Sch Med, Dept Surg, Sect Otolaryngol Head & Neck Surg, Calgary, AB, Canada
[4] Univ Calgary, Cumming Sch Med, Arnie Charbonneau Res Inst, Ohlson Res Initiat, Calgary, AB, Canada
[5] Skane Univ Hosp, Dept Plast & Reconstruct Surg, Malmo Jan Waldenstromsgata 18, SE-20502 Malmo, Sweden
[6] Lund Univ, Dept Clin Sci, Div Surg, Malmo, Sweden
来源：
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY | 2021年 / 6卷 / 05期
关键词：
alternative medicine; clinical outcomes; disease progression; head and neck cancer; treatment delay; BREAST-CANCER; COMPLEMENTARY; MULTICENTER; DISCLOSURE; SURVIVAL;
D O I：
10.1002/lio2.636
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background We investigated the alarming trend of curable head and neck cancer (HNC) patients forgoing conventional treatment to pursue alternative medicine (AM). Methods A prospectively maintained database identified HNC patients with >= 12 weeks from diagnosis to treatment initiation between 2012 and 2017. Reasons for delay were categorized and clinical stages and outcomes of AM patients were assessed through chart review by December 2019. Results Among 1462 patients with primary HNC, 68 patients (4.7%) were confirmed to delay initiation of potentially curative treatment, and 19 of these patients (28%) delayed treatment to pursue AM. Eleven of 19 AM patients transitioned from curative intent to palliation while exploring AM. Continued treatment rejection was common and outcomes corresponded to patients' degree of treatment adherence. Conclusions AM caused treatment delay and poor outcomes in potentially curable HNC. Improved knowledge among physicians regarding AM and complementary approaches is urgently needed to improve patient counseling. Level of Evidence Level 2c outcomes research.
引用
收藏
页码：991 / 998
页数：8
相关论文
共 42 条
[31]   Why are cancer patients using non-proven complementary therapies? A cross-sectional multicentre study in Norway [J].
Risberg, T ;
Kaasa, S ;
Wist, E ;
Melsom, H .
EUROPEAN JOURNAL OF CANCER, 1997, 33 (04) :575-580
[32]   Defining Criteria for Guiding Cancer Patients to Find a Reputable Complementary Medicine Provider: Results of a Literature Review and a Consensus Procedure [J].
Rogge, Alize A. ;
Baur, Isabel ;
Blettner, Gabriele ;
Holtkamp, Ulrike ;
Horneber, Markus ;
Jahn, Patrick ;
Joos, Stefanie ;
Keberle, Silva ;
Kettelgerdes, Anita ;
Klemperer, David ;
Laengler, Alfred ;
Voiss, Petra ;
Weis, Joachim ;
Witt, Claudia M. .
PATIENT PREFERENCE AND ADHERENCE, 2020, 14 :747-755
[33]   Disclosure to physicians of CAM use by breast cancer patients: Findings from the Women's Healthy Eating and Living Study [J].
Saxe, Gordon A. ;
Madlensky, Lisa ;
Kealey, Sheila ;
Wu, David P. H. ;
Freeman, Karen L. ;
Pierce, John P. .
INTEGRATIVE CANCER THERAPIES, 2008, 7 (03) :122-129
[34]  
Schiff BA, OROPHARYNGEAL SQUAMO
[35]   Use of complementary and alternative medicine by patients attending a head and neck oncology clinic [J].
Shakeel, M. ;
Newton, J. R. ;
Bruce, J. ;
Ah-See, K. W. .
JOURNAL OF LARYNGOLOGY AND OTOLOGY, 2008, 122 (12) :1360-1364
[36]  
Shumay D M, 2001, J Fam Pract, V50, P1067
[37]  
The Otobase™ clinical outcomes database, OT CLIN OUTC DAT OHL
[38]   COMPLEMENTARY AND ALTERNATIVE MEDICINE USE IN PATIENTS PRESENTING TO A HEAD AND NECK ONCOLOGY CLINIC [J].
Vyas, Tarren ;
Hart, Robert D. ;
Trites, Jonathan R. ;
Philips, Timothy J. ;
Archibald, Kathleen E. M. ;
Phillips, Judith E. ;
Taylor, S. Mark .
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2010, 32 (06) :793-799
[39]   Use of alternative medicine among patients with head and neck cancer [J].
Warrick, PD ;
Irish, JC ;
Morningstar, M ;
Gilbert, R ;
Brown, D ;
Gullane, P .
ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 1999, 125 (05) :573-579
[40]  
WHO, 2019, WHO GLOB REP TRAD CO
12345