IFN-γ: A cytokine at the right time, is in the right place

被引：185

作者：

Burke, J. Daniel ^{[1
]}

Young, Howard A. ^{[2
]}

机构：

[1] Frederick Natl Lab Canc Res, Leidos Biomed Res Inc, AIDS & Canc Virus Program, Frederick, MD 21701 USA

[2] NCI, Lab Expt Immunol, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21701 USA

来源：

SEMINARS IN IMMUNOLOGY | 2019年 / 43卷

关键词：

Interferon gamma; Tumor microenvironment; IL-12; Immunotherapy; Immunosuppression; TUMOR-INFILTRATING LYMPHOCYTES; REGULATORY T-CELLS; HIGH-DOSE INTERLEUKIN-2; RECEPTOR-BETA CHAIN; INTERFERON-GAMMA; IN-VIVO; NECROSIS-FACTOR; UP-REGULATION; ACQUIRED-RESISTANCE; HUMAN MACROPHAGES;

D O I：

10.1016/j.smim.2019.05.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interferon gamma has long been studied as a critical mediator of tumor immunity. In recent years, the complexity of cellular interactions that take place in the tumor microenvironment has become better appreciated in the context of immunotherapy. While checkpoint inhibitors have dramatically improved remission rates in cancer treatment, IFN-gamma and related effectors continue to be identified as strong predictors of treatment success. In this review, we provide an overview of the multiple immunosuppressive barriers that IFN-gamma has to overcome to eliminate tumors, and potential avenues for modulating the immune response in favor of tumor rejection.

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页数：8

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