IFN-γ: A cytokine at the right time, is in the right place

被引:184
作者
Burke, J. Daniel [1 ]
Young, Howard A. [2 ]
机构
[1] Frederick Natl Lab Canc Res, Leidos Biomed Res Inc, AIDS & Canc Virus Program, Frederick, MD 21701 USA
[2] NCI, Lab Expt Immunol, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21701 USA
关键词
Interferon gamma; Tumor microenvironment; IL-12; Immunotherapy; Immunosuppression; TUMOR-INFILTRATING LYMPHOCYTES; REGULATORY T-CELLS; HIGH-DOSE INTERLEUKIN-2; RECEPTOR-BETA CHAIN; INTERFERON-GAMMA; IN-VIVO; NECROSIS-FACTOR; UP-REGULATION; ACQUIRED-RESISTANCE; HUMAN MACROPHAGES;
D O I
10.1016/j.smim.2019.05.002
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Interferon gamma has long been studied as a critical mediator of tumor immunity. In recent years, the complexity of cellular interactions that take place in the tumor microenvironment has become better appreciated in the context of immunotherapy. While checkpoint inhibitors have dramatically improved remission rates in cancer treatment, IFN-gamma and related effectors continue to be identified as strong predictors of treatment success. In this review, we provide an overview of the multiple immunosuppressive barriers that IFN-gamma has to overcome to eliminate tumors, and potential avenues for modulating the immune response in favor of tumor rejection.
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页数:8
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