Extending the possibility of an N-Troc-protected sialic acid donor toward variant sialo-glycoside synthesis

被引：115

作者：

Ando, H

Koike, Y

Ishida, H

Kiso, M

机构：

[1] Gifu Univ, Dept Appl Bioorgan Chem, Gifu 5011193, Japan

[2] Japan Sci & Technol Corp, CREST, Gifu 5011193, Japan

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 36期

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

N-Troc group; sialidation; sialic acid analogs;

D O I：

10.1016/S0040-4039(03)01707-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The potential of an N-Troc-protected sialic acid donor, equipped with phenylsulfenyl functionality as a leaving group, has been explored. As a result, the entitled donor was proven to be highly reactive and to have broad applicability toward the synthesis of variant sialo-glycans, which have N-glycolyl, de-N-acetyl, 1,5-lactam and 8-O-sulfo sialic acid analogs. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：6883 / 6886

页数：4

共 34 条

[1] Lubricating cell signaling pathways with gangliosides [J].