Understanding HIV Latency: The Road to an HIV Cure

被引：172

作者：

Dahabieh, Matthew S. ^{[1
]}

Battivelli, Emilie ^{[1
]}

Verdin, Eric ^{[1
]}

机构：

[1] Univ Calif San Francisco, Gladstone Inst Virol & Immunol, San Francisco, CA 94941 USA

来源：

ANNUAL REVIEW OF MEDICINE, VOL 66 | 2015年 / 66卷

基金：

加拿大健康研究院;

关键词：

HIV-1; Tat; transcription; quiescence; lymphocyte; CD4(+) T-CELLS; IMMUNODEFICIENCY-VIRUS TYPE-1; IN-VITRO SYSTEM; INTEGRATED HIV-1; GENE-EXPRESSION; NUCLEAR-BODIES; P-TEFB; TRANSCRIPTIONAL ACTIVATION; DENDRITIC CELLS; VALPROIC ACID;

D O I：

10.1146/annurev-med-092112-152941

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Treatment with antiretroviral therapy dramatically increases the survival of HIV-infected individuals. However, treatment has to be continued for life because it does not lead to the full eradication of infection. HIV persists in resting CD4+ T cells, and possibly other cell types, and can reemerge from these cells when therapy is interrupted. Here, we review molecular mechanisms that have been proposed to contribute to HIV latency, as well as the relative roles of cis- and trans-acting mechanisms. We also discuss existing and future therapeutic opportunities regarding HIV latency that might lead to a future cure for HIV infection.

引用

页码：407 / 421

页数：15

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