Synthesis of Highly Substituted Pyrroles via Nucleophilic Catalysis

被引：74

作者：

Ngwerume, Simbarashe ^{[1
]}

Camp, Jason E. ^{[1
]}

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 18期

关键词：

BINDING-AFFINITY; O-VINYLOXIMES; DERIVATIVES; FACILE;

D O I：

10.1021/jo1011448

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A nucleophilic catalysis method providing a concise synthesis of di-, tri-, and tetrasubstituted pyrroles is described. This regioselective one-pot method relies on nucleophilic catalysis of the intermolecular addition of oximes to activated alkynes and thermal rearrangement of the in situ generated O-vinyl oximes to form pyrroles that contain a functional group handle at the C3/C4 position.

引用

页码：6271 / 6274

页数：4

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