Comparison of structure-dependent hormetic cytotoxicity induced by coplanar and non-coplanar PCB congeners

被引：7

作者：

Chen, Yingxu ^{[1
]}

Shen, Kaili ^{[1
]}

Shen, Chaofeng ^{[1
]}

Chen, Lei ^{[1
]}

Chen, Xincai ^{[1
]}

机构：

[1] Zhejiang Univ, Inst Environm Sci & Technol, Minist Agr Key Lab Nonpoint Source Pollut Control, Hangzhou 310029, Zhejiang, Peoples R China

来源：

JOURNAL OF HAZARDOUS MATERIALS | 2010年 / 180卷 / 1-3期

关键词：

PCBs; Hormesis; Cytotoxicity; Vero cells; POLYCHLORINATED-BIPHENYLS; AROMATIC-HYDROCARBONS; CELL-PROLIFERATION; HORMESIS; APOPTOSIS; RESPONSES; EXPOSURE; KIDNEY; WOMEN; VERO;

D O I：

10.1016/j.jhazmat.2010.04.041

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The effect of polychlorinated biphenyls (PCBs) on Vero cell proliferation was investigated, with the attempts to assess the possible hormetic dose-response and to compare their structure-dependent toxicity. Both PCB congeners revealed low doses stimulation in our experiment. However, significant cytotoxicity was only observed in PCB 52 concentrations larger than 0.1 mu g ml(-1), while there was no significant inhibition in PCB 77-treated cells at concentrations selected. Furthermore, the time-dependent cytotoxic trends were different. The comparison between PCB 52 and PCB 77 indicated that the cytotoxic mechanisms involved in coplanar or non-coplanar PCB congener exposure were different, and this difference might be associated with individual genotoxicity and the release of contact inhibition, respectively. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：773 / 776

页数：4

共 31 条

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