Disulfide-cleavage- and pH-triggered drug delivery based on a vesicle structured amphiphilic self-assembly

被引：23

作者：

Ding, Chengqiang ^{[1
]}

Wu, Hongwei ^{[2
]}

Yin, Zheng-Zhi ^{[3
]}

Gao, Jun ^{[4
]}

Wu, Datong ^{[1
]}

Qin, Yong ^{[1
]}

Kong, Yong ^{[1
]}

机构：

[1] Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab Adv Mat & Technol, Changzhou 213164, Peoples R China

[2] Xinxiang Med Univ, Dept Chem, Xinxiang 453000, Henan, Peoples R China

[3] Jiaxing Univ, Coll Biol Chem Sci & Engn, Jiaxing 314001, Peoples R China

[4] Nanjing Tradit Chinese Med Univ, Affiliated Hosp, Dept Orthoped, Changzhou 213003, Peoples R China

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2020年 / 107卷

基金：

中国国家自然科学基金;

关键词：

Multi-triggered drug delivery; Amphiphilicity; Vesicle structure; Self-assembly; Glutathione; CONTROLLED-RELEASE; ALPHA-TOCOPHEROL; IN-VITRO; MICELLES; VIVO; CHEMOTHERAPY; CHITOSAN; PLATFORM; SHELL;

D O I：

10.1016/j.msec.2019.110366

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Hydrophilic poly (acrylic acid) (PAA) and hydrophobic a-tocopherol succinate (TOS) were integrated via a two-step amidation with cystamine (Cys) as the linkage, and then the self-assembly of amphiphilic PAA-cys-TOS occurred in the aqueous solution of methorrexate (MTX), an anti-cancer drug, resulting a vesicle structured drug carrier. Since the disulfide (-S-S-) bridge of Cys is sensitive to glutathione (GSH) and the amide bonds in PAA-cys-TOS are sensitive to pH, disulfide-cleavage- and pH-triggered drug delivery was achieved with the amphiphilic self-assembly. Of particular interest was that the topography of the self-assembly varied remarkably during the triggered delivery, which was indicated by TEM results.

引用

页数：8

共 50 条

[1] Amphiphilic Janus Magnetoplasmonic Nanoparticles: pH-Triggered Self-Assembly and Fluorescence Modulation
Lu, Derong
Hou, Shuai
Liu, Sheng
Xiong, Qirong
Chen, Yonghao
Duan, Hongwei
JOURNAL OF PHYSICAL CHEMISTRY C, 2022, 126 (35): : 14967 - 14975
[2] Physiological pH-triggered morphological transition of amphiphilic block copolymer self-assembly
Wei Wu
Weigang Wang
Shuai Li
Jiantao Wang
Qiujing Zhang
Xiuhua Li
Xianglin Luo
Jianshu Li
Journal of Polymer Research, 2014, 21
[3] Physiological pH-triggered morphological transition of amphiphilic block copolymer self-assembly
Wu, Wei
Wang, Weigang
Li, Shuai
Wang, Jiantao
Zhang, Qiujing
Li, Xiuhua
Luo, Xianglin
Li, Jianshu
JOURNAL OF POLYMER RESEARCH, 2014, 21 (07)
[4] Mechanism of pH-triggered self-assembly of polysaccharide
Shen, Jana
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 250
[5] Self-Assembly of Drug-Drug Conjugates as Drug Self-Delivery System for Tumor-Specific pH-Triggered Release
Li, Jiagen
Liu, Peng
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 2019, 36 (07)
[6] Self-Assembly and Reassembly of Fiber-Forming Dipeptides for pH-Triggered DNA Delivery
Hafenstine, Glenn R.
Domaille, Dylan W.
Cha, Jennifer N.
Goodwin, Andrew P.
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2015, 53 (02) : 183 - 187
[7] Molecular basis of cooperativity in pH-triggered supramolecular self-assembly
Yang Li
Tian Zhao
Chensu Wang
Zhiqiang Lin
Gang Huang
Baran D. Sumer
Jinming Gao
Nature Communications, 7
[8] Morphology Transformation via pH-Triggered Self-Assembly of Peptides
Qin, Si-Yong
Xu, Sheng-Sheng
Zhuo, Ren-Xi
Zhang, Xian-Zheng
LANGMUIR, 2012, 28 (04) : 2083 - 2090
[9] Molecular basis of cooperativity in pH-triggered supramolecular self-assembly
Li, Yang
Zhao, Tian
Wang, Chensu
Lin, Zhiqiang
Huang, Gang
Sumer, Baran D.
Gao, Jinming
NATURE COMMUNICATIONS, 2016, 7
[10] Erratum: Molecular basis of cooperativity in pH-triggered supramolecular self-assembly
Yang Li
Tian Zhao
Chensu Wang
Zhiqiang Lin
Gang Huang
Baran D. Sumer
Jinming Gao
Nature Communications, 7

← 1 2 3 4 5 →