Relating Phage Genomes to Helicobacter pylori Population Structure: General Steps Using Whole-Genome Sequencing Data

被引：15

作者：

Vale, Filipa F. ^{[1
]}

Lehours, Philippe ^{[2
,3
]}

机构：

[1] Univ Lisbon, Fac Farm, Res Inst Med iMed ULisboa, Host Pathogen Interact Unit, P-1649003 Lisbon, Portugal

[2] Ctr Natl Reference Campylobacters & Helicobacters, Lab Bacteriol, Pl Amelie Raba Leon, F-33076 Bordeaux, France

[3] BaRITOn, INSERM, U1053, UMR Bordeaux Res Translat Oncol, F-33000 Bordeaux, France

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 07期

关键词：

phage; genome; phylogeography; Helicobacter pylori; evolution; DNA TRANSFER; PROPHAGES; RECOMBINATION; TOOL; BACTERIOPHAGES; IDENTIFICATION; TRANSFORMATION; METHYLATION; ANNOTATION; PREDICTION;

D O I：

10.3390/ijms19071831

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The review uses the Helicobacter pylori, the gastric bacterium that colonizes the human stomach, to address how to obtain information from bacterial genomes about prophage biology. In a time of continuous growing number of genomes available, this review provides tools to explore genomes for prophage presence, or other mobile genetic elements and virulence factors. The review starts by covering the genetic diversity of H. pylori and then moves to the biologic basis and the bioinformatics approaches used for studding the H. pylori phage biology from their genomes and how this is related with the bacterial population structure. Aspects concerning H. pylori prophage biology, evolution and phylogeography are discussed.

引用

页数：14

共 96 条

[21] Phages and the evolution of bacterial pathogens:: From genomic rearrangements to lysogenic conversion [J].