Acute D2 receptor blockade induces rapid, reversible remodeling in human cortical-striatal circuits

被引：102

作者：

Tost, Heike ^{[1
,2
]}

Braus, Dieter F. ^{[1
,3
]}

Hakimi, Shabnam ^{[2
]}

Ruf, Matthias ^{[1
,4
]}

Vollmert, Christian ^{[1
,5
]}

Hohn, Fabian ^{[1
]}

Meyer-Lindenberg, Andreas ^{[1
]}

机构：

[1] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, D-6800 Mannheim, Germany

[2] NIMH, Clin Brain Disorders Branch, Genes Cognit & Psychosis Program, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA

[3] Clin Psychiat & Psychotherapy, Dr Horst Schmidt Clin, Wiesbaden, Germany

[4] Heidelberg Univ, Med Fac Mannheim, Dept Neuroimaging, Cent Inst Mental Hlth, D-6800 Mannheim, Germany

[5] Heidelberg Univ, Med Fac Mannheim, Dept Addict Behav & Addict Med, Cent Inst Mental Hlth, D-6800 Mannheim, Germany

来源：

NATURE NEUROSCIENCE | 2010年 / 13卷 / 08期

基金：

美国国家卫生研究院;

关键词：

HALOPERIDOL; NEURONS; BRAIN; GENE;

D O I：

10.1038/nn.2572

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Structural remodeling has been observed in the human brain over periods of weeks to months, but the molecular mechanisms governing this process remain incompletely characterized. Using multimodal pharmaco-neuroimaging, we found that acute D-2 receptor blockade induced reversible striatal volume changes and structural-functional decoupling in motor circuits within hours; these alterations predicted acute extrapyramidal motor symptoms with high precision. Our findings suggest a role for D-2 receptors in short-term neural plasticity and identify a potential biomarker for neuroleptic side effects in humans.

引用

页码：920 / 922

页数：3

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