The role of the early social environment on Epstein Barr virus infection: a prospective observational design using the Millennium Cohort Study

被引:36
作者
Gares, V. [1 ,2 ]
Panico, L. [3 ]
Castagne, R. [1 ,2 ]
Delpierre, C. [1 ,2 ]
Kelly-Irving, M. [1 ,2 ]
机构
[1] INSERM, UMR1027, F-31000 Toulouse, France
[2] Univ Toulouse III Paul Sabatier, UMR1027, F-31000 Toulouse, France
[3] Inst Natl Etudes Demog, F-75980 Paris 20, France
关键词
Early infections; Epstein-Barr virus; Socioeconomic inequalities; UK; NHANES-III; CHILDREN; SEROPREVALENCE; PREVALENCE; CHILDHOOD; LYMPHOMA; AGE;
D O I
10.1017/S0950268817002515
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Epstein-Barr virus (EBV) is a highly prevalent herpesvirus linked to infectious mononucleosis and several malignancies. This paper aims to study the association between children's early life social environment at 9 months and EBV infection at 3 years of age. Methods We used data on children included in the UK Millennium Cohort Study. We described the social environment using area-level and material factors as well as socioeconomic position (SEP) at 9 months. EBV was measured at 3 years of age (n = 12 457). Results Lower rates of EBV infection were observed in children living in towns and rural areas compared with those living in cities. Lower SEP and overcrowding in the household increased the odds of being infected. Children whose parents were social tenants were more likely to be infected than homeowners. In the overall model, the strength of the association between material factors and EBV infection weakened. Conclusions We showed that early life material deprivation was associated with a higher risk of EBV infection among 3-year-olds. Children living in more deprived social conditions may be more likely to become EBV carriers at an earlier age.
引用
收藏
页码:3405 / 3412
页数:8
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