New Metabolites from the Marine-derived Fungus Aspergillus fumigatus

被引：1

作者：

Afiyatullov, Shamil Sh ^{[1
]}

Zhuravleva, Olesya I. ^{[1
]}

Antonov, Alexandr S. ^{[1
]}

Kalinovsky, Anatoly I. ^{[1
]}

Pivkin, Michail V. ^{[1
]}

Menchinskaya, Ekaterina S. ^{[1
]}

Aminin, Dmitry L. ^{[1
]}

机构：

[1] Russian Acad Sci, Far E Branch, Pacific Inst Bioorgan Chem, Vladivostok 690022, Russia

来源：

NATURAL PRODUCT COMMUNICATIONS | 2012年 / 7卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

Aspergillus fumigatus; Marine-derived fungus; Spiro-indole diketopiperazines; Fumiquinazolines; Nordammarane; Triterpenoid; ALKALOIDS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new alkaloid, fumiquinazoline K (1), and a new nordammarane triterpenoid (2), together with three known diketopiperazines (3-5) and tryptoquivaline F (6) have been isolated from a marine strain of Aspergillus fumigatus KMM 4631 associated with the soft coral Sinularia sp. Their structures were determined by FIR-MS and ID and 2D NMR. Compounds 3-5 exhibit weak cytotoxicity against cytoplasm non-specific esterase in Ehrlich carcinoma cells. Compound 3 also induces early apoptosis of the same cells in a non-toxic range of concentrations.

引用

页码：497 / 500

页数：4

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