New Metabolites from the Marine-derived Fungus Aspergillus fumigatus

被引：1
|
作者：
Afiyatullov, Shamil Sh [1 ]
Zhuravleva, Olesya I. [1 ]
Antonov, Alexandr S. [1 ]
Kalinovsky, Anatoly I. [1 ]
Pivkin, Michail V. [1 ]
Menchinskaya, Ekaterina S. [1 ]
Aminin, Dmitry L. [1 ]
机构：
[1] Russian Acad Sci, Far E Branch, Pacific Inst Bioorgan Chem, Vladivostok 690022, Russia
来源：
NATURAL PRODUCT COMMUNICATIONS | 2012年 / 7卷 / 04期
基金：
俄罗斯基础研究基金会;
关键词：
Aspergillus fumigatus; Marine-derived fungus; Spiro-indole diketopiperazines; Fumiquinazolines; Nordammarane; Triterpenoid; ALKALOIDS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new alkaloid, fumiquinazoline K (1), and a new nordammarane triterpenoid (2), together with three known diketopiperazines (3-5) and tryptoquivaline F (6) have been isolated from a marine strain of Aspergillus fumigatus KMM 4631 associated with the soft coral Sinularia sp. Their structures were determined by FIR-MS and ID and 2D NMR. Compounds 3-5 exhibit weak cytotoxicity against cytoplasm non-specific esterase in Ehrlich carcinoma cells. Compound 3 also induces early apoptosis of the same cells in a non-toxic range of concentrations.
引用
收藏
页码：497 / 500
页数：4
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