New Metabolites from the Marine-derived Fungus Aspergillus fumigatus

被引：1

作者：

Afiyatullov, Shamil Sh ^{[1
]}

Zhuravleva, Olesya I. ^{[1
]}

Antonov, Alexandr S. ^{[1
]}

Kalinovsky, Anatoly I. ^{[1
]}

Pivkin, Michail V. ^{[1
]}

Menchinskaya, Ekaterina S. ^{[1
]}

Aminin, Dmitry L. ^{[1
]}

机构：

[1] Russian Acad Sci, Far E Branch, Pacific Inst Bioorgan Chem, Vladivostok 690022, Russia

来源：

NATURAL PRODUCT COMMUNICATIONS | 2012年 / 7卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

Aspergillus fumigatus; Marine-derived fungus; Spiro-indole diketopiperazines; Fumiquinazolines; Nordammarane; Triterpenoid; ALKALOIDS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new alkaloid, fumiquinazoline K (1), and a new nordammarane triterpenoid (2), together with three known diketopiperazines (3-5) and tryptoquivaline F (6) have been isolated from a marine strain of Aspergillus fumigatus KMM 4631 associated with the soft coral Sinularia sp. Their structures were determined by FIR-MS and ID and 2D NMR. Compounds 3-5 exhibit weak cytotoxicity against cytoplasm non-specific esterase in Ehrlich carcinoma cells. Compound 3 also induces early apoptosis of the same cells in a non-toxic range of concentrations.

引用

页码：497 / 500

页数：4

共 50 条

[1] Three new dioxopiperazine metabolites from a marine-derived fungus Aspergillus fumigatus Fres.
Zhao, Wen Ying
Zhu, Tian Jiao
Fan, Guo Tao
Liu, Hong Bing
Fang, Yu Chun
Gu, Qian Qun
Zhu, Wei Ming
NATURAL PRODUCT RESEARCH, 2010, 24 (10) : 953 - 957
[2] A new gliotoxin analogue from a marine-derived fungus Aspergillus fumigatus Fres
Zhao, Wen Ying
Zhu, Tian Jiao
Han, Xiao Xian
Fan, Guo Tao
Liu, Hong Bing
Zhu, Wei Ming
Gu, Qian Qun
NATURAL PRODUCT RESEARCH, 2009, 23 (03) : 203 - 207
[3] Antitubercular metabolites from the marine-derived fungus strain Aspergillus fumigatus MF029
Song, Zhijun
Liu, Yu
Gao, Jieyu
Hu, Jiansen
He, Hongtao
Dai, Shengwang
Wang, Luoqiang
Dai, Huanqin
Zhang, Lixin
Song, Fuhang
NATURAL PRODUCT RESEARCH, 2021, 35 (16) : 2647 - 2654
[4] Discovery of Anti-MRSA Secondary Metabolites from a Marine-Derived Fungus Aspergillus fumigatus
Zhang, Rui
Wang, Haifeng
Chen, Baosong
Dai, Huanqin
Sun, Jingzu
Han, Junjie
Liu, Hongwei
MARINE DRUGS, 2022, 20 (05)
[5] Cytotoxicity Metabolites from Marine-Derived Fungus Aspergillus versicolor
Ya-yun Cai
Xiao-yan Jiang
Yu-qin Gu
Chemistry of Natural Compounds, 2023, 59 : 382 - 385
[6] New Metabolites from the Algal Associated Marine-derived Fungus Aspergillus carneus
Zhuravleva, Olesya I.
Afiyatullov, Shamil Sh.
Yurchenko, Ekaterina A.
Denisenko, Vladimir A.
Kirichuk, Natalya N.
Dmitrenok, Pavel S.
NATURAL PRODUCT COMMUNICATIONS, 2013, 8 (08) : 1071 - 1074
[7] Cytotoxicity Metabolites from Marine-Derived Fungus Aspergillus versicolor
Cai, Ya-yun
Jiang, Xiao-yan
Gu, Yu-qin
CHEMISTRY OF NATURAL COMPOUNDS, 2023, 59 (02) : 382 - 385
[8] Alkaloidal Metabolites from a Marine-Derived Aspergillus sp Fungus
Liao, Lijuan
You, Minjung
Chung, Beom Koo
Oh, Dong-Chan
Oh, Ki-Bong
Shin, Jongheon
JOURNAL OF NATURAL PRODUCTS, 2015, 78 (03): : 349 - 354
[9] Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7
Wang, Yu
Li, Da-Hong
Li, Zhan-Lin
Sun, Yan-Jun
Hua, Hui-Ming
Liu, Tao
Bai, Jiao
MOLECULES, 2016, 21 (01)
[10] In vitro induction of apoptosis by isosclerone from marine-derived fungus Aspergillus fumigatus
Li, Yong-Xin
Kang, Kyong-Hwa
Kim, Hak Jun
Kim, Se-Kwon
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (16) : 3923 - 3927

← 1 2 3 4 5 →