Enantioselective Rh(I)-Catalyzed Cyclization of Arylboron Compounds onto Ketones

被引：61

作者：

Low, Darryl W. ^{[1
]}

Pattison, Graham ^{[1
]}

Wieczysty, Martin D. ^{[1
]}

Churchill, Gwydion H. ^{[2
]}

Lam, Hon Wai ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Chem, EaStCHEM, Edinburgh EH9 3JJ, Midlothian, Scotland

[2] AstraZeneca, Proc Res & Dev, Macclesfield SK10 2NA, Cheshire, England

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 10期

基金：

英国工程与自然科学研究理事会;

关键词：

RHODIUM-CATALYZED ADDITION; CHIRAL DIENE LIGANDS; ASYMMETRIC-SYNTHESIS; OLEFIN LIGANDS; INTRAMOLECULAR ADDITION; ORGANOZINC REAGENTS; ORGANOBORONIC ACIDS; AROMATIC-ALDEHYDES; ALPHA-DIKETONES; ARYLATION;

D O I：

10.1021/ol300845q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rhodium complexes based upon chiral sulfinamide-alkene, TADDOL-derived phosphoramidite, or diene ligands catalyze cyclizations of arylboron compounds ono ketones, generating a variety of products containing five-, six-, or seven-membered rings with good yields and high enantioselectivities.

引用

页码：2548 / 2551

页数：4

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