Synthesis and pharmacological activities of some condensed 4-chloro-2,2-dialkyl chromene-3-carbaldehyde derivatives

被引：6

作者：

Hegab, Mohamed Ibrahim ^{[1
]}

Yousef, Nabil Mahmoud ^{[1
]}

Nour, Hany Fathy ^{[1
]}

Ellithey, Mohey ^{[2
]}

Arbid, Mahmoud Soliman ^{[2
]}

机构：

[1] Natl Res Ctr, Photochem Dept, Cairo, Egypt

[2] Natl Res Ctr, Dept Pharmacol, Cairo, Egypt

来源：

ACTA PHARMACEUTICA | 2008年 / 58卷 / 01期

关键词：

beta-chlorocarbaldehyde; hydrazones; thiosemicarbazones; oxime ethers; anti-inflammatory activity; ulcerogenic activity;

D O I：

10.2478/v10007-007-0042-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Some new hydrazono 5a, b, thiosemicarbazono 6a-c, and oximo chromenes 7a-c were prepared via the reaction of the corresponding beta-chlorocarbaldehyde 3 with hydrazine, aromatic hydrazine, thiosemicarbazide and hydroxylamine hydrochloride, respectively. In addition, ether derivatives 8a-h were prepared from the corresponding aldoximes 7a-c. The new products were tested for anti-inflammatory and ulcerogenic score activities compared to indomethacin.

引用

收藏

页码：15 / 27

页数：13

相关论文

共 22 条

[1] SYNTHESIS OF DIPYRAZOLO[3,4-B-4',3'-F]AZEPINES AND DITHIENO[2,3-B-3',2'F]-AZEPINES FROM 1-SUBSTITUTED 2,7-DICHLORO-4,5-DIHYDRO-1H-AZEPINE-3,6-DICARBALDEHYDES [J].

AUBERT, T ;

FARNIER, M ;

MEUNIER, I ;

GUILARD, R .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1989, (11) :2095-2098

[2]

CALVO AB, 1992, J CHEM SOC P1, P3075, DOI DOI 10.1039/P19920003075

[3] Synthesis and insect growth regulatory activity of alkoxy-substituted benzaldoxime ethers [J].

Chowdhury, H ;

Saxena, VS ;

Walia, S .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1998, 46 (02) :731-736

[4] NAPHTHO[1,2-B]THIOPHEN .1. PREPARATION AND ELECTROPHILIC SUBSTITUTION [J].

CLARKE, K ;

GREGORY, DN ;

SCROWSTO.RM .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1973, (23) :2956-2960

[5]

Dijk J. V., 1977, J MED CHEM, V20, P1199

[6] Synthesis and investigation of mass spectra of 3-[5′-(2′-substituent)-thienyl]benzo[5,6]coumarins [J].

El-Deen, IM ;

Abd El-Fattah, M ;

Ibrahim, HK ;

El-Gohary, A .

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2003, 178 (07) :1463-1476

[7]

El-Deen IM, 1999, CHINESE J CHEM, V17, P391

[8] Cycloadditions with 2,2-dialkyl-3-thioxochroman-4-one S-sulfides including an unprecedented [3+5] cycloaddition [J].

El-Essawy, FAG ;

Yassin, SM ;

El-Sakka, IA ;

Khattab, AF ;

Sotofte, I ;

Madsen, JO ;

Senning, A .

JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (26) :9840-9845

[9] A NOVEL SYNTHESIS OF 4-HALO-2H-CHROMENES [J].

ESZENYI, T ;

TIMAR, T ;

SEBOK, P .

TETRAHEDRON LETTERS, 1991, 32 (06) :827-828

[10] 4-chloro-2,2-disubstituted chromen-3-carboxaldehyde: Synthesis of some fused polycyclic heterocycles as anti-inflammatory, analgesic, anticonvulsant, and anti parkinsonian agents [J].

Hegab, MI ;

Abdulla, MM .

ARCHIV DER PHARMAZIE, 2006, 339 (01) :41-47