Notch and Neurogenesis

被引：69
作者：
Engler, Anna [1 ]
Zhang, Runrui [1 ]
Taylor, Verdon [1 ]
机构：
[1] Univ Basel, Dept Biomed, Embryol & Stem Cell Biol, Basel, Switzerland
来源：
MOLECULAR MECHANISMS OF NOTCH SIGNALING | 2018年 / 1066卷
关键词：
Neurogenesis; Development; Notch; Rbpj; Hes; Central nervous system; Maintenance; Neural stem cells; Subventricular zone; Dentate gyrus; NEURAL STEM-CELLS; NERVOUS-SYSTEM; SUBVENTRICULAR ZONE; IN-VIVO; ADULT NEUROGENESIS; EMBRYONIC ORIGIN; NEWBORN NEURONS; MAINTENANCE; QUIESCENT; PROGENITOR;
D O I：
10.1007/978-3-319-89512-3_11
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neurogenesis is the process of forming neurons and is essential during vertebrate development to produce most of the neurons of the adult brain. However, neurogenesis continues throughout life at distinct locations in the vertebrate brain. Neural stem cells (NSCs) are the origin of both embryonic and adult neurogenesis, but their activity and fate are tightly regulated by their local milieu or niche. In this chapter, we will discuss the role of Notch signaling in the control of neurogenesis and regeneration in the embryo and adult. Notch-dependence is a common feature among NSC populations, we will discuss how differences in Notch signaling might contribute to heterogeneity among adult NSCs. Understanding the fate of multiple NSC populations with distinct functions could be important for effective brain regeneration.
引用
收藏
页码：223 / 234
页数：12
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