Single-Molecule Studies of Viral DNA Packaging

被引：35

作者：

Chemla, Yann R. ^{[1
]}

Smith, Douglas E. ^{[2
]}

机构：

[1] Univ Illinois, Dept Phys, Ctr Phys Living Cells, Ctr Biophys & Computat Biol, Urbana, IL 61801 USA

[2] Univ Calif San Diego, Dept Phys, San Diego, CA 92093 USA

来源：

VIRAL MOLECULAR MACHINES | 2012年 / 726卷

关键词：

BACTERIOPHAGE-LAMBDA TERMINASE; OPTICAL TWEEZERS; FORCE GENERATION; LARGE SUBUNIT; PORTAL MOTOR; DSDNA BACTERIOPHAGES; EJECTION FORCES; HIGH-RESOLUTION; ATPASE ACTIVITY; INTERNAL FORCE;

D O I：

10.1007/978-1-4614-0980-9_24

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Many double-stranded DNA bacteriophages and viruses use specialized ATP-driven molecular machines to package their genomes into tightly confined procapsid shells. Over the last decade, single-molecule approaches - and in particular, optical tweezers - have made key contributions to our understanding of this remarkable process. In this chapter, we review these advances and the insights they have provided on the packaging mechanisms of three bacteriophages: phi 29, lambda, and T4.

引用

页码：549 / 584

页数：36

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