Construction of Silver Nanoparticle-Loaded Micelles Via Coordinate Interaction and Their Antibacterial Activity

被引：5
|
作者：
Huang, Gang [1 ,2 ]
Tong, Guoquan [1 ,2 ]
Liu, Jie [1 ,2 ]
Zhang, Wei [3 ]
Chen, Ling [1 ]
Quan, Changyun [1 ,2 ]
Jiang, Qing [1 ,2 ]
Sun, Hongtao [4 ]
Zhang, Chao [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Sch Engn, Guangzhou 510006, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Guangdong Prov Key Lab Sensor Technol & Biomed In, Guangzhou 510006, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Outpatient, Guangzhou 510006, Guangdong, Peoples R China
[4] Guangdong 2 Prov Peoples Hosp, Dept Orthopaed, Guangzhou 510317, Guangdong, Peoples R China
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2015年 / 64卷 / 16期
关键词：
Antibacterial activity; coordination; micelle; silver nanoparticle; POLYMER VESICLES; POLYACRYLAMIDE; COMPOSITES; TRANSITION; NANOFIBERS; EFFICACY; SURFACE; GROWTH;
D O I：
10.1080/00914037.2015.1030655
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Silver nanoparticles (AgNPs) loaded antibacterial micelles were fabricated utilizing the coordinate interaction between silver ion (Ag+) and methoxy-poly(ethylene glycol)-block-poly(acrylamide-co-acrylonitrile) followed by in situ reduction. This micelle was characterized by X-ray photoelectron spectroscopy, transmission electron microscopy, and dynamic light scattering. The upper critical solution temperature of Ag+-loaded micelles was dependent on Ag+ concentration. The AgNPs were approximately 4nm in diameter and homogenously distributed in the micelles. The AgNPs-loaded micelle displayed high stability during a one week study and excellent antibacterial activity against gram-negative Escherichia coli and was of acceptable toxicity toward human embryonic hepatocytes.
引用
收藏
页码：848 / 856
页数：9
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