Blood-brain barrier dysfunction, status epilepticus, seizures, and epilepsy: A puzzle of a chicken and egg?

被引：101

作者：

Friedman, Alon ^{[1
]}

机构：

[1] Ben Gurion Univ Negev, Dept Physiol & Neurobiol, Zlotowski Ctr Neurosci Ben Gurion, IL-84105 Beer Sheva, Israel

来源：

EPILEPSIA | 2011年 / 52卷

基金：

以色列科学基金会;

关键词：

Astrocytes; Microglia; Serum albumin; Transforming growth factor beta; EPILEPTOGENESIS; DISRUPTION;

D O I：

10.1111/j.1528-1167.2011.03227.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Status epilepticus is often associated with endothelial dysfunction and increased vessels permeability. We discuss here the direct role of blood-brain barrier (BBB) dysfunction in epileptogenesis and brain damage. On the cellular level, astrocytes respond early to the efflux of serum proteins in the presence of dysfunctional BBB, with activation of the innate immune system and disturbed homeostasis of extracellular potassium and glutamate. In turn, there is enhanced excitability of neurons and altered network connectivity. Transforming growth factor beta (TGF-beta) signaling appears to be a potential new target for the prevention of epileptogenesis and secondary damage following status epilepticus.

引用

收藏

页码：19 / 20

页数：2

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