Identification of 26RFa from frog brain - A novel hypothalamic neuropeptide with orexigenic activity in mammals

被引：13
作者：
Chartrel, N [1 ]
Bruzzone, F
Dujardin, C
Leprince, J
Tollemer, H
Anouar, Y
Vallarino, M
Costentin, J
Vaudry, H
机构：
[1] Univ Rouen, INSERM, U413, IFRMP 23,Lab Cellular & Mol Neuroendocrinol, F-76821 Mont St Aignan, France
[2] Univ Genoa, Dept Expt Biol, Genoa, Italy
来源：
TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY | 2005年 / 1040卷
关键词：
neuropeptide; RFamide peptide; amphibians; mammals; brain; feeding;
D O I：
10.1196/annals.1327.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the present study, we report the identification, in the frog brain, of a novel neuropeptide, termed 26RFa, that belongs to the RFamide peptide family. The cDNAs encoding the precursors for 26RFa have been characterized in human and rats. In rats, prepro-26RFa mRNA is expressed exclusively in two. hypothalamic nuclei involved in the control of feeding behavior. Intra-cerebroventricular injection of 26RFa in mice induced a dose-dependent increase in food consumption. Taken together, these data indicate that 26RFa is a novel neuropeptide that may have important biological functions in vertebrates.
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收藏
页码：80 / 83
页数：4
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