Psychostimulants, L-type calcium channels, kinases, and phosphatases

被引：27
作者：
Rajadhyaksha, AM
Kosofsky, BE
机构：
[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Mol & Dev Neurosci Lab, Charlestown, MA 02129 USA
[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Martinos Ctr Biomed Imaging,Dept Radiol, Charlestown, MA 02129 USA
来源：
NEUROSCIENTIST | 2005年 / 11卷 / 05期
关键词：
drug addiction; Ca(v)1.2; Ca(v)1.3; ventral tegmental area; nucleus accumbens; striatum; phosphorylation;
D O I：
10.1177/1073858405278236
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
There is growing evidence for the role of voltage-gated L-type Ca2+ channels in mediating aspects of the addictive properties of psychostimulants. L-type Ca2+ channels activate Ca2+ second-messenger pathways that regulate protein phosphorylation and thereby activation of target gene expression. Here the authors will review recent progress in our understanding of L-type Ca2+ channel-activated signal transduction pathways that contribute to molecular neuroadaptations evident following acute and chronic exposures to psychostimulants.
引用
收藏
页码：494 / 502
页数：9
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