No association of psychosis in Alzheimer disease with neurodegenerative pathway genes

被引：18

作者：

DeMichele-Sweet, Mary Ann A. ^{[1
]}

Klei, Lambertus ^{[1
]}

Devlin, Bernie ^{[1
]}

Ferrell, Robert E. ^{[2
]}

Weamer, Elise A. ^{[1
,3
]}

Emanuel, James E. ^{[1
]}

Lopez, Oscar L. ^{[1
,3
]}

Sweet, Robert A. ^{[1
,3
,4
]}

机构：

[1] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15213 USA

[4] VA Pittsburgh Healthcare Syst, VISN Mental Illness Res 4, Educ & Clin Ctr MIRECC, Pittsburgh, PA USA

来源：

NEUROBIOLOGY OF AGING | 2011年 / 32卷 / 03期

关键词：

Alzheimer's disease; Psychosis; Amyloid precursor protein (APP); Beta-site amyloid precursor protein cleaving enzyme (BACE1); Sortilin-related receptor (SORL1); Microtubule-associated protein tau (MAPT); Apolipoprotein E e4 (APOE e4);

D O I：

10.1016/j.neurobiolaging.2010.10.003

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Psychotic symptoms occur in approximately 40% of subjects with Alzheimer disease (AD with psychosis; AD + P) and identify a subgroup with more rapid cognitive decline. We evaluated in 867 AD subjects the association of AD + P with genes which may modify the pathological process via effects on the accumulation of amyloid beta (A beta) protein and/or hyperphosphorylated microtubule-associated protein tau (MAPT): amyloid precursor protein (APP), beta-site amyloid precursor protein cleaving enzyme (BACE1), sortilin-related receptor (SORL1), and MAPT. Each gene was thoroughly interrogated with tag single-nucleotide polymorphisms (SNPs), and gene-based tests were used to enhance power. We found no association of these genes with AD + P. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：555.e9 / 555.e11

页数：3