The serotonin system and spiritual experiences

被引:144
作者
Borg, J [1 ]
Andrée, B [1 ]
Soderstrom, H [1 ]
Farde, L [1 ]
机构
[1] Karolinska Hosp & Inst, Dept Clin Neurosci, Psychiat Sect, SE-17176 Stockholm, Sweden
关键词
D O I
10.1176/appi.ajp.160.11.1965
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: The serotonin system has long been of interest in biological models of human personality. The purpose of this positron emission tomography (PET) study was to search for relationships between serotonin 5-HT1A receptor density and personality traits. Method: Fifteen normal male subjects, ages 20-45 years, were examined with PET and the radioligand [C-11]WAY100635. Personality traits were assessed with the Swedish version of the Temperament and Character Inventory self-report questionnaire. Binding potential, an index for the density of available 5-HT1A receptors, was calculated for the dorsal raphe nuclei, the hippocampal formation, and the neocortex. For each region, correlation coefficients between 5-HT1A receptor binding potential and Temperament and Character Inventory personality dimensions were calculated and analyzed in two-tailed tests for significance. Results: The authors found that the binding potential correlated inversely with scores for self-transcendence, a personality trait covering religious behavior and attitudes. No correlations were found for any of the other six Temperament and Character Inventory dimensions. The self-transcendence dimension consists of three distinct subscales, and further analysis showed that the subscale for spiritual acceptance correlated significantly with binding potential but not with the other two subscales. Conclusions: This finding in normal male subjects indicated that the serotonin system may serve as a biological basis for spiritual experiences. The authors speculated that the several-fold variability in 5-HT1A receptor density may explain why people vary greatly in spiritual zeal.
引用
收藏
页码:1965 / 1969
页数:5
相关论文
共 30 条
[11]   A PSYCHOBIOLOGICAL MODEL OF TEMPERAMENT AND CHARACTER [J].
CLONINGER, CR ;
SVRAKIC, DM ;
PRZYBECK, TR .
ARCHIVES OF GENERAL PSYCHIATRY, 1993, 50 (12) :975-990
[12]   D2 dopamine receptors and personality traits [J].
Farde, L ;
Gustavsson, JP ;
Jonsson, E .
NATURE, 1997, 385 (6617) :590-590
[13]   VARIABILITY IN D-2-DOPAMINE RECEPTOR DENSITY AND AFFINITY - A PET STUDY WITH [C-11] RACLOPRIDE IN MAN [J].
FARDE, L ;
HALL, H ;
PAULI, S ;
HALLDIN, C .
SYNAPSE, 1995, 20 (03) :200-208
[14]   The effects and consequences of selected club drugs [J].
Freese, TE ;
Miotto, K ;
Reback, CJ .
JOURNAL OF SUBSTANCE ABUSE TREATMENT, 2002, 23 (02) :151-156
[15]  
GLENNON RA, 1990, NEUROPSYCHOPHARMACOL, V3, P509
[16]   Tracer kinetic modeling of the 5-HT1A receptor ligand [carbonyl-11C]WAY-100635 for PET [J].
Gunn, RN ;
Sargent, PA ;
Bench, CJ ;
Rabiner, EA ;
Osman, S ;
Pike, VW ;
Hume, SP ;
Grasby, PM ;
Lammertsma, AA .
NEUROIMAGE, 1998, 8 (04) :426-440
[17]   Autoradiographic localization of 5-HT1A receptors in the post-mortem human brain using [H-3]WAY-100635 and [C-11]WAY-100635 [J].
Hall, H ;
Lundkvist, C ;
Halldin, C ;
Farde, L ;
Pike, VW ;
McCarron, JA ;
Fletcher, A ;
Cliffe, IA ;
Barf, T ;
Wikstrom, H ;
Sedvall, G .
BRAIN RESEARCH, 1997, 745 (1-2) :96-108
[18]   Molecular, pharmacological and functional diversity of 5-HT receptors [J].
Hoyer, D ;
Hannon, JP ;
Martin, GR .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2002, 71 (04) :533-554
[19]  
Kirk K M, 1999, Twin Res, V2, P81, DOI 10.1375/136905299320565942
[20]  
KOE BK, 1966, J PHARMACOL EXP THER, V154, P499