Palladium-catalyzed three-component approach to promazine with formation of one carbon-sulfur and two carbon-nitrogen bonds

被引：109

作者：

Dahl, Troels ^{[2
]}

Tornoe, Christian W. ^{[1
]}

Bang-Andersen, Benny ^{[1
]}

Nielsen, Poul ^{[2
]}

Jorgensen, Morten ^{[1
]}

机构：

[1] Med Chem Res, DK-2500 Copenhagen, Denmark

[2] Univ So Denmark, Dept Chem, DK-5270 Odense, Denmark

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 09期

关键词：

aryl amination; homogeneous catalysis; multicomponent reactions; palladium; sulfur heterocycles;

D O I：

10.1002/anie.200705209

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Presented) Zip it up! The use of a Pd/dppf catalyst gives access to the tricyclic phenothiazine scaffold starting from 1-bromo-2-iodobenzenes, aliphatic or aromatic amines, and 2-bromothiophenols in a single reaction flask (see scheme; dppf=1,1′-bis(diphenylphosphanyl) ferrocene; dba=dibenzylidineacetone). This transformation involves thioether formation and subsequent intermolecular and intramolecular aryl amination reactions. The reaction occurs in good overall yield and selectivity. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1726 / 1728

页数：3

共 29 条

[1]

[Anonymous], ANGEW CHEM

[2]

BOGESO KP, 2002, TXB DRUG DESIGN DISC, pCH11

[3] Carbon-nitrogen-bond-forming reductive elimination of arylamines from palladium(II) phosphine complexes [J].