Clinical application of mesenchymal stem cells in rheumatic diseases

被引:15
作者
Wang, Yajing [1 ]
Ma, Dan [1 ]
Wu, Zewen [1 ]
Yang, Baoqi [1 ]
Li, Rong [1 ]
Zhao, Xingxing [2 ]
Yang, Helin [2 ]
Zhang, Liyun [1 ]
机构
[1] Shanxi Med Univ, Shanxi Bethune Hosp, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Hosp 3, Taiyuan 030032, Peoples R China
[2] Shanxi Univ Chinese Med, Jinzhong 030619, Shanxi, Peoples R China
基金
中国国家自然科学基金;
关键词
Mesenchymal stem cells; Rheumatic diseases; Clinical application; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ANKYLOSING-SPONDYLITIS; STROMAL CELLS; CLASSIFICATION CRITERIA; TRANSPLANTATION; THERAPY; SPONDYLOARTHRITIS; SCLEROSIS; SAFETY; DIFFERENTIATION;
D O I
10.1186/s13287-021-02635-9
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Mesenchymal stem cells (MSCs) are pluripotent stem cells derived from mesoderm during early development that are characterized by high self-renewal ability and multidirectional differentiation potential. These cells are present various tissues in the human body and can be cultured in vitro. Under specific conditions, MSCs can differentiate into osteoblasts, neuron-like cells, adipocytes and muscle cells and so on, therefore, have a great application value in cell replacement therapy and tissue repair. In recent years, the application of MSCs in rheumatic diseases has received increasing attention. On the one hand, MSCs have the ability to differentiate into bone and cartilage cells; on the other hand, these stem cells are also involved in immune regulation, resulting in the alleviation of inflammation and anti-fibrotic properties and the promotion of vascular repair, thus bringing new hope for the treatment of rheumatic diseases. This article reviews the clinical progress in MSC application for the treatment of rheumatic diseases.
引用
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页数:8
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