Mammary epithelioid myofibroblastoma mimicking invasive carcinoma: case report and literature review

被引:0
作者
Jing, Qiu-Yang [1 ]
Liu, Li [2 ]
Zhong, Biao [3 ]
Zhu, Lu-Hong [2 ]
Chen, Zhi-Ying [2 ]
Liu, Wei [4 ]
Wei, Ya-Ni [1 ]
Wei, Bing [1 ]
机构
[1] Sichuan Univ, West China Hosp, Dept Pathol, 37 Guoxuexiang, Chengdu 610041, Sichuan, Peoples R China
[2] Chengdu Univ, Affiliated Hosp, Dept Pathol, Chengdu, Sichuan, Peoples R China
[3] Chengdu Univ, Affiliated Hosp, Dept Breast Surg, Chengdu, Sichuan, Peoples R China
[4] Chengdu Univ, Affiliated Hosp, Dept Color Ultrason, Chengdu, Sichuan, Peoples R China
来源
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2017年 / 10卷 / 10期
基金
中国国家自然科学基金;
关键词
Breast; epithelioid myofibroblastoma; differential diagnosis; immunohistochemistry; CELL MYOFIBROBLASTOMA; MORPHOLOGIC-SPECTRUM; POTENTIAL PITFALL; BREAST; EXPRESSION; LESIONS; TUMOR;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Myofibroblastoma (MFB) of the breast is a rare benign neoplasm, which exhibits several morphologic variants and presents diagnostic dilemmas for pathologists. Here, we describe a case of a 42-year-old female patient diagnosed as epithelioid MFB. This painless tumor was well-circumscribed and found in the left breast for three months. Histologically, this tumor was predominantly composed of epithelioid cells, which arranged as single cells or small clusters, and formed a cellular nodule. Tumor stroma was collagenized, with scattered myxoid areas. This case was misinterpreted as invasive lobular carcinoma in the original diagnosis. Immunohistochemical profile demonstrated positivity for desmin, SMA, calponin, CD34 and hormone receptors, whereas pan-CK, CK7, CK8, CK34bE12, CK5/6, EMA, p63 and S-100 were negative, confirming the diagnosis of epithelioid MFB. Awareness of this unusual variant and careful integration of clinicopathologic findings would be critical to diagnosis this challenging lesion and avoid potential diagnostic pitfalls.
引用
收藏
页码:10640 / 10646
页数:7
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