Gene expression of COX-2, MLH1 and MSH2 in papillary thyroid carcinoma: a retrospective analysis

Objetives: To determine the mRNA expression of the COX-2, MLH1 and MSH2 genes in Papillary Thyroid Carcinoma. Methods: This is comparative cross-sectional clinical molecular study. The study was constituted by 26 biopsies with histopathological diagnosis of Papillary Thyroid Carcinoma, from the 450 General Hospital of Durango State. The relative gene expression of the COX-2, MLH1 and MSH2 was performed by qPCR. Results: The mean age of patients was 46 +/- 15.22. They were observed differences in the gene expression of COX-2 (p = 0.001), MLH1 (p = 0.06) and MSH2 (p = 0.09) in the total Papillary Thyroid Carcinoma sample. The correlation between gene expression and patient age was r(2) = 0.441 (p = 0.024) for the MSH2 gene. The correlation of mRNA expression between COX-2 and MLH1 was r(2) = 0.69 (p = 0.001); for COX-2 and MSH2 of r(2) = 0.47 (p = 0.01), while for MSH1 and MSH2 of r(2) = 0.94 (p = 0.001). Conclusions: The results obtained in the present study showing the presence of gene expression of molecular targets such as the COX-2, MLH1 and MSH2 genes, contributing to the understanding of the molecular physiopathology of the Papillary Thyroid Carcinoma.