Physico chemical characterization of two processes of macropores elaboration for biphasic calcium phosphate ceramics

The use of micro and macroporous biphasic calcium phosphate ceramics in orthopedic surgery and more generally in bone filling are more and more used in replacement of allograft. The hybrid bone or STEM cell tissue engineering are also in place to supply of the autograft. This specific material must be macroporous. The technology generally used is polymer sponge impregnated with a green of calcium phosphate followed by a pyrolysis process. The technology we have developed until today for the macropores elaboration in our material from 15 years are based on the sublimation of naphtalin balls. The inconvenient is the smelling, and the auto ignition over 500 degreesC. The purpose of this study was to developed a macropores processing using other porogen. We have selected from various porogen of sugar origin like saccharose. We have determined the physical characteristic of such biphasic macroporous implant comparing to classical material obtain with naphtalin porogen and demonstrated that fundamental structural and chemical properties are preserved using sugar porogens, before to perform in vivo biofunctionality to achieve the demonstration and to use in human clinical situation such materials.