PRELIMINARY RESEARCH REGARDING CHEMICAL COMPOSITION AND ANTI-INFLAMMATORY EFFECTS OF POLYGONUM PLEBEIUM R. BR

Polygonum plebeium is a medicinal plant, traditionally used to treat diseases associated with inflammation. The purpose of this study was to assess the anti-inflammatory effect of the aqueous methanolic extract of Polygonum plebeium (AMEPP). The plant inhibitory potential against protein denaturation was determined by measuring the absorbance of the plant extract treated with bovine serum and egg albumin solutions. The pant in vivo anti-inflammatory activity was examined by using carrageenan and egg albumin induced paw oedema models. The AMEPP has inhibited the egg albumin and bovine serum albumin denaturation (72.99% and 67.51%, respectively) dose depending. The plant extract has significantly reduced inflammation (48.7% and 40.63%, respectively) against carrageenan and egg albumin-induced paw oedema models. The present study concludes that the AMEPP has a promising anti-inflammatory effect which could be related to the presence of the secondary metabolites. The current study confirmed the traditional use of P. plebeium extract in inflammatory conditions.