Slipped-strand mispairing can function as a phase variation mechanism in Escherichia coli

被引：49

作者：

Torres-Cruz, J ^{[1
]}

van der Woude, MW ^{[1
]}

机构：

[1] Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USA

来源：

JOURNAL OF BACTERIOLOGY | 2003年 / 185卷 / 23期

关键词：

D O I：

10.1128/JB.185.23.6990-6994.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Slipped-strand mispairing (SSM) has not been identified as a mechanism of phase variation in Escherichia coli. Using a reporter gene, we show that sequences that cause phase variation by SSM in Haemophilus influenzae also lead to phase variation when introduced onto the chromosome of E. coli, and the frequencies of switching are in the biologically relevant range. Thus, the absence of SSM-mediated phase variation in E. coli does not appear to be due to a mechanistic constraint.

引用

页码：6990 / 6994

页数：5

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