Prospective surveillance of women with a family history of breast cancer: auditing the risk threshold

被引：5

作者：

Anderson, E. ^{[2
]}

Berg, J. ^{[3
]}

Black, R. ^{[4
]}

Bradshaw, N. ^{[5
]}

Campbell, J. ^{[2
]}

Carnaghan, H. ^{[1
]}

Cetnarkyj, R. ^{[2
]}

Drummond, S. ^{[2
]}

Davidson, R. ^{[5
]}

Dunlop, J. ^{[3
]}

Fordyce, A. ^{[4
]}

Gibbons, B. ^{[6
]}

Goudie, D. ^{[3
]}

Gregory, H.

Holloway, S. ^{[2
]}

Longmuir, M. ^{[5
]}

McLeish, L. ^{[3
]}

Murday, V. ^{[5
]}

Miedzybrodska, Z. ^{[6
]}

Nicholson, D. ^{[4
]}

Pearson, P. ^{[2
]}

Porteous, M.

Reis, M. ^{[3
]}

Slater, S. ^{[2
]}

Smith, K. ^{[4
]}

Smyth, E. ^{[4
]}

Snadden, L. ^{[5
]}

Steel, M. ^{[1
]}

Stirling, D.

Watt, C.

Whyte, C. ^{[2
]}

Young, D. ^{[3
]}

机构：

[1] Univ St Andrews, Brute Med Sch, St Andrews K16 9TS, Fife, Scotland

[2] Western Gen Hosp, Dept Clin Genet, Edinburg Breast Canc Family Serv, Edinburg Breast Unit, Edinburgh EH4 2XU, Midlothian, Scotland

[3] Ninewells Hosp, Dept Clin Genet, Dundee Breast Canc Family Serv, Dundee DD1 9SY, Scotland

[4] NHS Scotland Informat Serv Div, Epidemiol & Stat Grp, Scottish Canc Reg, Edinburgh EH12 9EB, Midlothian, Scotland

[5] Yorkhill Hosp, Ferguson Smith Ctr Clin Genet, Glasgow Breast Canc Family Serv, Glasgow G3 8SJ, Lanark, Scotland

[6] Aberdeen Royal Infirm, Dept Med Genet, Aberdeen Breast Canc Family Serv, Aberdeen AB25 2ZD, Scotland

来源：

BRITISH JOURNAL OF CANCER | 2008年 / 98卷 / 04期

关键词：

breast cancer; familial; risk assessment;

D O I：

10.1038/sj.bjc.6604155

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To evaluate current guidelines criteria for inclusion of women in special 'breast cancer family history' surveillance programmes, records were reviewed of women referred to Scottish breast cancer family clinics between January 1994 and December 2003 but discharged as at 'less than 'moderate' familial risk'. The Scottish Cancer Registry was then interrogated to determine subsequent age-specific incidence of breast cancer in this cohort and corresponding Scottish population figures. Among 2074 women, with an average follow-up of 4.0 years, 28 invasive breast cancers were recorded up to December 2003, where 14.4 were expected, a relative risk (RR) of 1.94. Eleven further breast cancers were recorded between January 2004 and February 2006 (ascertainment incomplete for this period). The overall RR for women in the study cohort exceeded the accepted 'cutoff' level (RR = 1.7) for provision of special counselling and surveillance. The highest RR was found for the age group 45-59 years and this group also generated the majority of breast cancers. The National Institute for Clinical Excellence ('NICE') guidelines appear to be more accurate than those of the Scottish Intercollegiate Guidelines Network ('SIGN') in defining 'moderate' familial risk, and longer follow-up of this cohort could generate an evidence base for further modification of familial breast cancer services.

引用

页码：840 / 844

页数：5

共 14 条

[11]

*SIGN, 1998, BREAST CANC WOM

[12]

*UK PUBL HLTH GEN, 1998, REP CONS M MAN WOM F

[13]

WATSON E, 1999, FAMILIAL BREAST OVAR

[14]

2004, BREAST CANC RISK FAC

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