Lawsozaheer, a new chromone produced by an endophytic fungus Paecilomyces variotii isolated from Lawsonia Alba Lam. inhibits the growth of Staphylococcus aureus

被引：9

作者：

Abbas, Zaheer ^{[1
]}

Siddiqui, Bina Shaheen ^{[1
]}

Shahzad, Saleem ^{[2
]}

Sattar, Samia ^{[2
]}

Begum, Sabira ^{[3
]}

Batool, Anum ^{[1
]}

Choudhary, Mohammad Iqbal ^{[1
,3
]}

机构：

[1] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi, Pakistan

[2] Univ Karachi, Dept Agr & Agribusiness Management, Karachi, Pakistan

[3] Icing Abdnlaziz Univ, Fac Sci, Dept Biochem, Jeddah, Saudi Arabia

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 22期

关键词：

Lawsonia alba Lam; Paecilomyces variotii; antimicrobial activity; Staphylococcus aureus; Candida albicans; INERMIS L; STEROLS;

D O I：

10.1080/14786419.2020.1729148

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

One new chromone, lawsozaheer (1), and five known compounds 4-(2-hydroxyethyl) phenol (2), viriditoxin (3), stigmasta-4,6,8(14),22-tetraen-3-one (4), beta-sitosterol (5) and stigmasterol (6) were isolated from the fungal broth of Paecilomyces variotii. Their structures were elucidated using spectroscopic data. The configuration of 1 was determined by Horeau's method. The broth extract and compound 1 showed highly selective activity against Staphylococcus aureus (NCTC 6571) bacterium with 83.19 and 84.26% inhibition respectively at 150 mu g/mL, comparing well with that of standard drug ofloxacin (87.013% inhibition at 100 mu g/mL). Broth extract also showed 75, and 40% inhibition of Candida albicans and Fusarium lini, respectively.

引用

页码：4448 / 4453

页数：6