Prospects for incorporation of epigenetic biomarkers in human health and environmental risk assessment of chemicals

被引:22
|
作者
Jeremias, Guilherme [1 ,2 ]
Goncalves, Fernando J. M. [1 ,2 ]
Pereira, Joana L. [1 ,2 ]
Asselman, Jana [3 ]
机构
[1] Univ Aveiro, Dept Biol, P-3810193 Aveiro, Portugal
[2] Univ Aveiro, CESAM Ctr Environm & Marine Studies, P-3810193 Aveiro, Portugal
[3] Univ Ghent, Environm Toxicol Unit GhEnToxLab, Lab Environm Toxicol & Aquat Ecol, B-9000 Ghent, Belgium
关键词
epigenetic biomarkers; chemical exposure; environmental epigenetics; environmental risk assessment; human and ecological health; prospective and retrospective assessment; GLOBAL DNA METHYLATION; EPIGENOME-WIDE ASSOCIATION; PRENATAL ALCOHOL EXPOSURE; TUMOR-SUPPRESSOR GENE; ENDOCRINE DISRUPTION; CIGARETTE-SMOKING; SEDIMENT QUALITY; MARBLED CRAYFISH; AGOUTI MOUSE; CANCER;
D O I
10.1111/brv.12589
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Epigenetic mechanisms have gained relevance in human health and environmental studies, due to their pivotal role in disease, gene x environment interactions and adaptation to environmental change and/or contamination. Epigenetic mechanisms are highly responsive to external stimuli and a wide range of chemicals has been shown to determine specific epigenetic patterns in several organisms. Furthermore, the mitotic/meiotic inheritance of such epigenetic marks as well as the resulting changes in gene expression and cell/organismal phenotypes has now been demonstrated. Therefore, epigenetic signatures are interesting candidates for linking environmental exposures to disease as well as informing on past exposures to stressors. Accordingly, epigenetic biomarkers could be useful tools in both prospective and retrospective risk assessment but epigenetic endpoints are currently not yet incorporated into risk assessments. Achieving a better understanding on this apparent impasse, as well as identifying routes to promote the application of epigenetic biomarkers within environmental risk assessment frameworks are the objectives of this review. We first compile evidence from human health studies supporting the use of epigenetic exposure-associated changes as reliable biomarkers of exposure. Then, specifically focusing on environmental science, we examine the potential and challenges of developing epigenetic biomarkers for environmental fields, and discuss useful organisms and appropriate sequencing techniques to foster their development in this context. Finally, we discuss the practical incorporation of epigenetic biomarkers in the environmental risk assessment of chemicals, highlighting critical data gaps and making key recommendations for future research within a regulatory context.
引用
收藏
页码:822 / 846
页数:25
相关论文
共 50 条
  • [1] Biomarkers in environmental and human health risk assessment
    Galloway, Tamara S.
    MARINE POLLUTION BULLETIN, 2006, 53 (10-12) : 606 - 613
  • [2] Prioritising environmental chemicals for human health risk assessment
    Hughes, J
    Courage, C
    Capleton, A
    Duarte-Davidson, R
    TOXICOLOGY, 2001, 168 (01) : 73 - 73
  • [3] The Future of Human Health Risk Assessment of Environmental Chemicals
    Hodgson, Ernest
    TOXICOLOGY AND HUMAN ENVIRONMENTS, 2012, 112 : 307 - 322
  • [4] Application of OMICS data to human health risk assessment of environmental chemicals
    Ge, Yue
    Bruno, Maribel
    Preston, Julian
    Ross, Jeffrey
    TOXICOLOGY LETTERS, 2009, 189 : S40 - S40
  • [5] Biomarkers and environmental risk assessment: Guiding principles from the human health field
    Owen, Richard
    Galloway, Tamara S.
    Hagger, Josephine A.
    Jones, Malcolm B.
    Depledge, Michael H.
    MARINE POLLUTION BULLETIN, 2008, 56 (04) : 613 - 619
  • [6] Epigenetic Regulation in Environmental Chemical Carcinogenesis and its Applicability in Human Health Risk Assessment
    Kuppusamy, Senthilkumar P.
    Kaiser, J. Phillip
    Wesselkamper, Scott C.
    INTERNATIONAL JOURNAL OF TOXICOLOGY, 2015, 34 (05) : 384 - 392
  • [7] Biomarkers: Coming of age for environmental health and risk assessment
    Decaprio, AP
    ENVIRONMENTAL SCIENCE & TECHNOLOGY, 1997, 31 (07) : 1837 - 1848
  • [8] RISK ASSESSMENT OF ENVIRONMENTAL CHEMICALS
    FAN, A
    HOWD, R
    DAVIS, B
    ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1995, 35 : 341 - 368
  • [9] RISK ASSESSMENT OF ENVIRONMENTAL CHEMICALS
    MERIAN, E
    CHEMOSPHERE, 1978, 7 (04) : 307 - 313
  • [10] Environmental and human health risk assessment
    Lahaniatis, MR
    Pakalin, S
    Kettrup, A
    FRESENIUS ENVIRONMENTAL BULLETIN, 2002, 11 (10A): : 713 - 735